LEADER 05729nam 22006615 450 001 9910298334103321 005 20200630080754.0 010 $a1-4939-1311-5 024 7 $a10.1007/978-1-4939-1311-4 035 $a(CKB)3710000000280763 035 $a(EBL)1965010 035 $a(OCoLC)899003465 035 $a(SSID)ssj0001385843 035 $a(PQKBManifestationID)11752091 035 $a(PQKBTitleCode)TC0001385843 035 $a(PQKBWorkID)11351779 035 $a(PQKB)10954288 035 $a(MiAaPQ)EBC1965010 035 $a(DE-He213)978-1-4939-1311-4 035 $a(PPN)183087135 035 $a(EXLCZ)993710000000280763 100 $a20141112d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMacrophages: Biology and Role in the Pathology of Diseases$b[electronic resource] /$fedited by Subhra K. Biswas, Alberto Mantovani 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (603 p.) 300 $aDescription based upon print version of record. 311 $a1-4939-1310-7 320 $aIncludes bibliographical references. 327 $aPart I Macrophage: Origin, Activation And Polarization -- Blood monocytes and their subsets in health and disease -- Polarized activation of macrophages -- Alternative activation of macrophages: concepts and prospects -- Regulatory macrophages and the maintenance of homeostasis -- Part II Macrophages And Their Diverse Functions -- Phagocytosis -- The antimicrobial functions of macrophages -- Vascular modulatory functions of macrophages -- Part III Macrophages In Different Tissues -- Airway macrophages: sentinels of health -- Microglial ontogeny and functions in shaping brain circuits -- Kupffer cells in health and disease -- Intestinal Macrophages: Specialized antigen-presenting cells at the front line -- Part IV Macrophages In Pathology -- The wound macrophage - Macrophages and the entrance of resolution phase lipid mediators -- Macrophages in sepsis progression -- Adaptive characteristics of innate immune responses in macrophages -- African trypanosomiasis as paradigm for involvement of the mononuclear phagocyte system in pathogenicity during parasite infection -- Macrophages in obesity and insulin resistance -- Macrophages govern the progression and termination of inflammation in atherosclerosis and metabolic diseases -- Myelomonocytic subsets in tumor microenvironment -- Tumor associated macrophages -- Part V Transcriptional And Epigenetic Mechanisms -- Role of NF-kB activation in macrophages -- Interferon Regulatory Factors: Role in transcriptional regulation of macrophage plasticity and activation -- Kruppel-like factors in Monocyte-Macrophage Biology -- Regulation of macrophage polarization by the STAT-SOCS signaling axis -- Functions of the large Maf transcription factors and macrophages -- The Control of Gene Expression in Macrophages -- Role of microRNA in macrophage activation and polarization -- Part VI Systems Biology Of Macrophages -- The macrophage transcriptome -- Omics approaches in macrophage biology -- Appendix. 330 $aMacrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue microenvironmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease- virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts to provide state-of-the art knowledge of these cells in health and disease. 606 $aImmunology 606 $aAntibodies 606 $aMedical microbiology 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aAntibodies$3https://scigraph.springernature.com/ontologies/product-market-codes/B14010 606 $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003 615 0$aImmunology. 615 0$aAntibodies. 615 0$aMedical microbiology. 615 14$aImmunology. 615 24$aAntibodies. 615 24$aMedical Microbiology. 676 $a571967 676 $a610 676 $a616.0798 676 $a616.9041 702 $aBiswas$b Subhra K$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMantovani$b Alberto$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298334103321 996 $aMacrophages: Biology and Role in the Pathology of Diseases$92544736 997 $aUNINA