LEADER 04355nam 2200601Ia 450 001 9910298331703321 005 20170821182809.0 010 $a1-4614-7931-2 024 7 $a10.1007/978-1-4614-7931-4 035 $a(CKB)2670000000420767 035 $a(EBL)1398491 035 $a(OCoLC)858763753 035 $a(SSID)ssj0000986626 035 $a(PQKBManifestationID)11527943 035 $a(PQKBTitleCode)TC0000986626 035 $a(PQKBWorkID)10938550 035 $a(PQKB)11257172 035 $a(MiAaPQ)EBC1398491 035 $a(DE-He213)978-1-4614-7931-4 035 $a(PPN)172420245 035 $a(EXLCZ)992670000000420767 100 $a20111102d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSystems analysis of chromatin-related protein complexes in cancer /$fAndrew Emili, Jack Greenblatt, Shoshana Wodak, editors 210 $aNew York $cSpringer Science$d2014 215 $a1 online resource (320 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-7930-4 320 $aIncludes bibliographical references and index. 327 $aPreface -- Systematic proteomic analysis of histone demethylating enzymes linked to cancer -- Histone methylating protein complexes in cancer -- Chromatin protein-protein interaction networks linked to cancer -- Structural genomics and drug discovery for chromatin-related protein complexes involved in histone tail recognition -- Transcription factories and global chromatin (enhancer) interactions in cancer -- Long ncRNAs associated with chromatin complexes and their role in cancer -- Familial and somatic mutations of histone modifying enzymes in cancer -- Chromatin regulators arising from RNAi screens of transformed cancer cell lines -- Chromatin complexes in cancer -- Exploring dynamics of chromatin complexes in cancer based on quantitative proteomics -- Regulatory ncRNAs and their targets -- ncRNA regulatory networks in cancer -- Decoding BAF remodelling complexes in cancer -- Mediator/cohesin complex in cancer -- miRNAs targeting chromatin-related protein complexes regulate epigenetic states in cancer -- Polycomb group protein complexes in cancer stem cells -- Genetic interactions between chromatin factors in cancer cell lines -- Chromatin complexes in DNA repair -- Chromatin complexes in chromosome segregation -- Evolution, co-expression and domain architecture of CM complexes linked to cancer -- Index. 330 $aEpigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie  environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned ?on? or ?off? and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines  - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks. 606 $aChromosomal proteins 606 $aTumor proteins 615 0$aChromosomal proteins. 615 0$aTumor proteins. 676 $a570 676 $a572.6 676 $a599935 676 $a610 701 $aEmili$b Andrew$01060280 701 $aGreenblatt$b Jack$01060281 701 $aWodak$b Shoshana J$01060282 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298331703321 996 $aSystems analysis of chromatin-related protein complexes in cancer$92512253 997 $aUNINA