LEADER 04504nam 22007695 450 001 9910298331603321 005 20200706103837.0 010 $a1-4471-6458-X 024 7 $a10.1007/978-1-4471-6458-6 035 $a(CKB)3710000000168075 035 $a(EBL)1781966 035 $a(SSID)ssj0001295344 035 $a(PQKBManifestationID)11724566 035 $a(PQKBTitleCode)TC0001295344 035 $a(PQKBWorkID)11342860 035 $a(PQKB)10486353 035 $a(MiAaPQ)EBC1781966 035 $a(DE-He213)978-1-4471-6458-6 035 $a(PPN)179926578 035 $a(EXLCZ)993710000000168075 100 $a20140707d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAnticancer Genes /$fedited by Stefan Grimm 205 $a1st ed. 2014. 210 1$aLondon :$cSpringer London :$cImprint: Springer,$d2014. 215 $a1 online resource (288 p.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v818 300 $aDescription based upon print version of record. 311 $a1-322-13233-X 311 $a1-4471-6457-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroductory chapter -- Viral Anticancer Genes.- Signalling of apoptin -- Apoptin towards safe and efficient anticancer therapies -- Introduction of cancer-specific cell death by the adenovirus E4orf4 protein -- Tumor Suppressing Properties of Rodent Parvovirus NS1 Proteins and their Derivatives -- Cellular Anticancer Genes -- MDA-7/IL-24: Multifunctional Cancer Killing Cytokine -- Cancer-Selective Apoptosis by Tumor Suppressor Par-4 -- Tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL) -- SIRT6: a promising target for cancer prevention and therapy -- An Overview of Brevinin Superfamily: Structure, Function and Clinical Perspectives -- Isolation and Characterisation of the Anticancer Gene Organic Cation Transporter Like-3 (ORCTL3).- Anticancer Gene Therapy -- Introduction of Genes via Sonoporation and Electroporation -- Anticancer Gene Transfer for Cancer Gene Therapy. 330 $aThis book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as ?Anticancer Genes?, are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells. With contributions from experts worldwide, Anticancer Genes is an essential guide to this dynamic topic for researchers and students in cancer research, molecular medicine, pharmacology and toxicology and genetics as well as clinicians and clinical researchers interested in the therapeutic potential of this exciting new field. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v818 606 $aMolecular biology 606 $aCancer$xResearch 606 $aGene therapy 606 $aHuman genetics 606 $aPharmacology 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aGene Therapy$3https://scigraph.springernature.com/ontologies/product-market-codes/B12020 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 615 0$aMolecular biology. 615 0$aCancer$xResearch. 615 0$aGene therapy. 615 0$aHuman genetics. 615 0$aPharmacology. 615 14$aMolecular Medicine. 615 24$aCancer Research. 615 24$aGene Therapy. 615 24$aHuman Genetics. 615 24$aPharmacology/Toxicology. 676 $a616.994042 702 $aGrimm$b Stefan$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298331603321 996 $aAnticancer Genes$92526755 997 $aUNINA