LEADER 04694nam 22006015 450 001 9910298330803321 005 20200704035246.0 010 $a1-4939-1304-2 024 7 $a10.1007/978-1-4939-1304-6 035 $a(CKB)3710000000311419 035 $a(EBL)1968559 035 $a(OCoLC)897466424 035 $a(SSID)ssj0001407842 035 $a(PQKBManifestationID)11755974 035 $a(PQKBTitleCode)TC0001407842 035 $a(PQKBWorkID)11411570 035 $a(PQKB)10076249 035 $a(MiAaPQ)EBC1968559 035 $a(DE-He213)978-1-4939-1304-6 035 $z(PPN)258860537 035 $a(PPN)183150252 035 $a(EXLCZ)993710000000311419 100 $a20141201d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aApplied Pharmacometrics /$fedited by Stephan Schmidt, Hartmut Derendorf 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (570 p.) 225 1 $aAAPS Advances in the Pharmaceutical Sciences Series,$x2210-7371 ;$v14 300 $aDescription based upon print version of record. 311 $a1-4939-1303-4 320 $aIncludes bibliographical references and index. 327 $a1 Introduction to Pharmacometrics and Quantitative Pharmacology with an Emphasis on Physiologically Based Pharmacokinetics -- 2 Personalized Medicine ? Integrating Individual Exposure and Response Information at the Bedside -- 3 Pharmacometrics in Pediatrics -- 4 Pharmacometrics in Chronic Kidney Disease -- 5 Drug-Disease Model-Based Development of Therapeutic Agents for Treatment of Diabetes -- 6 Applied Pharmacometrics in the Obese Population -- 7 Pharmacometrics in Cardiovascular Safety -- 8 Pharmacometrics in Bacterial Infections -- 9 Pharmacometrics in Viral Infections -- 10 Applied Antifungal Pharmacometrics: Fluconazole and Echinocandins in the Treatment of Candidemia and Invasive Candidiasis -- 11 Pharmacometrics and Tuberculosis -- 12 Pharmacometrics in Pulmonary Diseases -- 13 State-of-the-Art Pharmacometric Models in Osteoporosis -- 14 Pharmacometrics in Psychiatric Diseases -- 15 Clinical Trial Simulation in Alzheimer?s Disease -- 16 Pharmacometric Applications in Inflammation -- 17 Pharmacometrics in Dermatology -- 18 Pharmacometrics in Pain Management -- 19 Pharmacometrics of Hyperlipidemia. 330 $aThis comprehensive volume provides an update on the current state of pharmacometrics in drug development. It consists of nineteen chapters all written by leading scientists from the pharmaceutical industry, regulatory agencies and academia. After an introduction of the basic pharmacokinetic and pharmacodynamic concepts of pharmacometrics in drug development, the book presents numerous examples of specific applications that utilize pharmacometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, diabetes, obesity, infections, psychiatrics, Alzheimer?s disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process. Applying pharmacometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, pharmacometrics has an important economic impact in drug product selection.  Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, pharmacometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success. 410 0$aAAPS Advances in the Pharmaceutical Sciences Series,$x2210-7371 ;$v14 606 $aPharmaceutical technology 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 615 0$aPharmaceutical technology. 615 14$aPharmaceutical Sciences/Technology. 676 $a615.1 702 $aSchmidt$b Stephan$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDerendorf$b Hartmut$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298330803321 996 $aApplied Pharmacometrics$92544091 997 $aUNINA