LEADER 03894nam 22006255 450 001 9910298329203321 005 20200629163304.0 010 $a3-319-09498-X 024 7 $a10.1007/978-3-319-09498-4 035 $a(CKB)3710000000251954 035 $a(EBL)1965461 035 $a(OCoLC)893224979 035 $a(SSID)ssj0001372124 035 $a(PQKBManifestationID)11734785 035 $a(PQKBTitleCode)TC0001372124 035 $a(PQKBWorkID)11301842 035 $a(PQKB)11172372 035 $a(MiAaPQ)EBC1965461 035 $a(DE-He213)978-3-319-09498-4 035 $a(PPN)182093840 035 $a(EXLCZ)993710000000251954 100 $a20141006d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBacterial Activation of Type I Interferons$b[electronic resource] /$fedited by Dane Parker 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (133 p.) 300 $aDescription based upon print version of record. 311 $a3-319-09497-1 320 $aIncludes bibliographical references and index. 327 $aProduction and action of type I interferons in host defense -- Induction and consequences of the type I IFN response to Listeria monocytogenes -- Innate immune and type I IFN responses during Legionella pneumophila infection -- Type I interferons in immune defense against streptococci -- Activation of type I IFN signaling by Staphylococcus aureus -- Contribution of interferon signaling to host defense against Pseudomonas aeruginosa -- The detrimental role of type I interferon signaling during infection with Salmonella typhimurium -- Yersinia activation of type I interferon -- Induction and Function of Type I IFNs During Chlamydial Infection -- Regulation of Host Response to Mycobacteria by Type I Interferons. 330 $aThe type I interferon (IFN) signaling pathway is well recognized as a pathway activated by viral infections. It is activated by a variety of microbial pattern recognition receptors including the Toll-like receptors, NOD-like receptors and several cytosolic receptors. Activation of the type I IFN pathway leads to the production of both antiviral factors and products that influence immune cell function. More recently it has been shown that bacteria are also capable of activating this pathway. Bacterial Activation of Type I Interferons reviews both the current understanding of how different bacterial species are able to activate this pathway as well as the influence type I IFNs have on the outcome to infection. Several different bacterial species are covered, spanning Gram positive and Gram negative, intracellular, extracellular, and different host infection sites. An introduction to the pathogenesis of each organism is provided, and the signaling molecules involved in the activation of the type I IFN pathway and the role it plays in animal infection models are also covered. 606 $aBacteriology 606 $aImmunology 606 $aInfectious diseases 606 $aBacteriology$3https://scigraph.springernature.com/ontologies/product-market-codes/L23012 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aInfectious Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33096 615 0$aBacteriology. 615 0$aImmunology. 615 0$aInfectious diseases. 615 14$aBacteriology. 615 24$aImmunology. 615 24$aInfectious Diseases. 676 $a579.3 676 $a616.9 702 $aParker$b Dane$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298329203321 996 $aBacterial Activation of Type I Interferons$92544731 997 $aUNINA