LEADER 04324nam  22007095  450 
001 9910298328603321
005 20200630020602.0
010   $a1-4614-5915-X
024 7 $a10.1007/978-1-4614-5915-6
035   $a(CKB)3710000000073787
035   $a(EBL)1592631
035   $a(SSID)ssj0001066565
035   $a(PQKBManifestationID)11630022
035   $a(PQKBTitleCode)TC0001066565
035   $a(PQKBWorkID)11067902
035   $a(PQKB)11094616
035   $a(MiAaPQ)EBC1592631
035   $a(DE-He213)978-1-4614-5915-6
035   $a(PPN)176097805
035   $a(EXLCZ)993710000000073787
100   $a20131123d2014      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aTumor Microenvironment and Cellular Stress $eSignaling, Metabolism, Imaging, and Therapeutic Targets /$fedited by Constantinos Koumenis, Ester Hammond, Amato Giaccia
205   $a1st ed. 2014.
210  1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014.
215   $a1 online resource (293 p.)
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v772
300   $aDescription based upon print version of record.
311   $a1-4614-5914-1 
320   $aIncludes bibliographical references and index.
327   $aIntroduction -- Hypoxia and metabolism in cancer -- Hypoxia and Regulation of Cancer Cell Stemness -- Hypoxia-mediated metastasis -- Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell?s Perspective -- Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy -- Hypoxia directed drug strategies to target the tumor microenvironment -- Radiotherapy and the Tumor Microenvironment: Mutual Influence and Clinical Implications -- Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapeutic -- Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer -- miR-210: Fine-Tuning the Hypoxic Response -- The role of complement in tumor growth -- Imaging angiogenesis, inflammation and metastasis in the tumor microenvironment with magnetic resonance imaging -- Index.
330   $aThe collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v772
606   $aCancer research
606   $aImmunology
606   $aHuman physiology
606   $aMedical microbiology
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
606   $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004
606   $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003
615  0$aCancer research.
615  0$aImmunology.
615  0$aHuman physiology.
615  0$aMedical microbiology.
615 14$aCancer Research.
615 24$aImmunology.
615 24$aHuman Physiology.
615 24$aMedical Microbiology.
676   $a616.994
702   $aKoumenis$b Constantinos$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aHammond$b Ester$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aGiaccia$b Amato$4edt$4http://id.loc.gov/vocabulary/relators/edt
712 12$aAegean Meeting on the Tumor Microenvironment and Cellular Stress$d(1st :$f2012 :$eCrete, Greece)
906   $aBOOK
912   $a9910298328603321
996   $aTumor Microenvironment and Cellular Stress$92503151
997   $aUNINA