LEADER 03496nam 22006735 450 001 9910298327903321 005 20200630072344.0 010 $a3-319-08921-8 024 7 $a10.1007/978-3-319-08921-8 035 $a(CKB)3710000000218682 035 $a(EBL)1802970 035 $a(SSID)ssj0001338298 035 $a(PQKBManifestationID)11710511 035 $a(PQKBTitleCode)TC0001338298 035 $a(PQKBWorkID)11338187 035 $a(PQKB)11056021 035 $a(MiAaPQ)EBC1802970 035 $a(DE-He213)978-3-319-08921-8 035 $a(PPN)180624253 035 $a(EXLCZ)993710000000218682 100 $a20140805d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aIntrinsically Disordered Proteins /$fby Vladimir N. Uversky 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (73 p.) 225 1 $aProtein Folding and Structure,$x2199-3157 300 $aDescription based upon print version of record. 311 $a1-322-13767-6 311 $a3-319-08920-X 320 $aIncludes bibliographical references. 327 $aIntroducing the phenomenon of protein intrinsic disorder -- Peculiar amino acid sequences of soluble IDPs -- Natural abundance of IDPs/IDPRs -- Wavy evolution of intrinsic disorder: Reinventing the wheel -- Structural heterogeneity of IDPs: When almost everything is possible -- Typical functions of IDPs and IDPRs -- Binding promiscuity and multitude of the disorder-based binding modes -- IDPs/IDPRs in human diseases -- IDPs as potential drug targets -- Concluding remarks: Intrinsic disorder as a universal tool for solving protein mysteries and riddles. 330 $aIn this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas. 410 0$aProtein Folding and Structure,$x2199-3157 606 $aProteins 606 $aPharmaceutical chemistry 606 $aBiochemistry 606 $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 615 0$aProteins. 615 0$aPharmaceutical chemistry. 615 0$aBiochemistry. 615 14$aProtein Structure. 615 24$aMedicinal Chemistry. 615 24$aBiochemistry, general. 676 $a572.633 700 $aUversky$b Vladimir N$4aut$4http://id.loc.gov/vocabulary/relators/aut$0873541 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298327903321 996 $aIntrinsically Disordered Proteins$92536202 997 $aUNINA LEADER 02630nam 2200625Ia 450 001 9910967840503321 005 20251117073043.0 010 $a1-282-04295-5 010 $a9786612042959 010 $a1-4438-0284-0 035 $a(CKB)2420000000004638 035 $a(EBL)1133017 035 $a(OCoLC)830168532 035 $a(SSID)ssj0000298904 035 $a(PQKBManifestationID)11243588 035 $a(PQKBTitleCode)TC0000298904 035 $a(PQKBWorkID)10236003 035 $a(PQKB)11304975 035 $a(MiAaPQ)EBC1133017 035 $a(Au-PeEL)EBL1133017 035 $a(CaPaEBR)ebr10677024 035 $a(CaONFJC)MIL204295 035 $a(OCoLC)929645992 035 $a(FlNmELB)ELB108094 035 $a(EXLCZ)992420000000004638 100 $a20080805d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aHow did I survive? /$fby Artavazd M. Minasyan ; edited, annotated, translation and introduction by Aleksandr V. Gevorkyan 210 $aNewcastle, UK $cCambridge Scholars Pub.$d2008 210 1$aNewcastle, UK :$cCambridge Scholars Pub.,$d2008. 215 $a1 online resource (189 p.) 300 $aDescription based upon print version of record. 311 08$a1-4438-7598-8 311 08$a1-84718-601-7 320 $aIncludes bibliographical references (p. [165]). 327 $aTABLE OF CONTENTS; EDITOR'S NOTE; PREFACE; PROLOGUE; CHILDHOOD; YOUTH AND MATURITY; IN THE ARMY; THE WAR; THE YEARS AFTER THE WAR; ROSTOV-NA-DONU; HOW MY BOOKS WERE PUBLISHED; CONCLUSION; EPILOGUE; GLOSSARY; MAJOR BOOKS; NOTES 330 $aHow Did I Survive? is a book of memoirs of Professor Artavazd M. Minasyan. It is a tale of one man's life and his survival despite all odds. It is a story that inspires life and hope. It is a story in which the good ultimately prevails over the evil. It is also a tale of a country that has lived through decades of controversies, destruction and injustice. The author unveils intricate details of his time describing his fight for survival and what inspired and gave him strength to go on. Profe... 606 $aPhilosophers$zSoviet Union$vBiography 607 $aSoviet Union$xHistory 608 $aLibros electro?nicos. 615 0$aPhilosophers 676 $a947.084092 700 $aMinasi?a?n$b A. M$g(Artavazd Mikhai?lovich)$01897738 701 $aGevorkyan$b Aleksandr V$0887944 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910967840503321 996 $aHow did I survive$94553015 997 $aUNINA