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010   $a3-319-12766-7
024 7 $a10.1007/978-3-319-12766-8
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035   $a(OCoLC)900887006
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035   $a(DE-He213)978-3-319-12766-8
035   $a(PPN)183149491
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100   $a20141212d2014      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aMolecular Mechanisms Underpinning the Development of Obesity /$fedited by Clévio Nóbrega, Raquel Rodriguez-López
205   $a1st ed. 2014.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014.
215   $a1 online resource (200 p.)
300   $aDescription based upon print version of record.
311   $a3-319-12765-9 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aChallenges in understanding development of obesity -- Monogenic forms of obesity -- Heterogeneous obesity syndromes: new strategies for diagnosis -- Genetic contribution: common forms of obesity -- The role of the GWAS identified FTO locus in regulating body size and composition -- Neural vulnerability factors that increase risk for weight gain: prevention and treatment implications -- Molecular mechanisms involved in the regulation of food intake -- Epigenetics of human obesity: a link between genetics and nutrition -- MicroRNAs in obesity and metabolism -- Obesity study: animal models -- From Homo obesus to Homo diabesus: neuroadipology insight -- Obesity and type 2 diabetes.
330   $aObesity is a multi-factorial disease, in which an excess of accumulated body fat can reach levels capable of affecting health. It results from an interplay between environmental factors, eating behavior, genes, epigenetics, and neuronal stimuli. The book provides a state-of-the-art revision about the molecular mechanisms underpinning the development of obesity, reviewing the current knowledge in areas like monogenic and polygenic obesity forms, while also providing an updated view of the emerging knowledge about epigenetics, nutrigenomics, and neuronal aspects that also contribute to obesity.
606   $aHuman genetics
606   $aBiochemistry
606   $aCell biology
606   $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008
606   $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
615  0$aHuman genetics.
615  0$aBiochemistry.
615  0$aCell biology.
615 14$aHuman Genetics.
615 24$aBiochemistry, general.
615 24$aCell Biology.
676   $a571.6
676   $a572
676   $a599935
676   $a610
702   $aNóbrega$b Clévio$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aRodriguez-López$b Raquel$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298327403321
996   $aMolecular Mechanisms Underpinning the Development of Obesity$92522647
997   $aUNINA