LEADER 05803nam 22006615 450 001 9910298327103321 005 20200703041142.0 010 $a1-4939-0859-6 024 7 $a10.1007/978-1-4939-0859-2 035 $a(CKB)3710000000186927 035 $a(EBL)1782039 035 $a(SSID)ssj0001295349 035 $a(PQKBManifestationID)11709597 035 $a(PQKBTitleCode)TC0001295349 035 $a(PQKBWorkID)11337301 035 $a(PQKB)10869554 035 $a(MiAaPQ)EBC1782039 035 $a(DE-He213)978-1-4939-0859-2 035 $a(PPN)179922092 035 $a(EXLCZ)993710000000186927 100 $a20140709d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCancers in People with HIV and AIDS$b[electronic resource] $eProgress and Challenges /$fedited by Robert Yarchoan 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (385 p.) 300 $aDescription based upon print version of record. 311 $a1-322-13301-8 311 $a1-4939-0858-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aHIV-associated Cancers: Overview -- Epidemiology of AIDS-defining Malignancies -- Epidemiology of non-AIDS Defining Malignancies -- HIV Cancers in Resource-limited Regions -- Kaposi's Sarcoma-associated Herpesvirus (KSHV) -- Epstein Barr Virus (EBV) -- Human Papillomavirus (HPV) -- Merkel Cell Polymavirus (MCV) -- Presentation and Pathogenesis of Kaposi's Sarcoma -- Management of Kaposi's Sarcoma -- Presentation and Pathogenesis of HIV Lymphomas -- Diffuse Large B-Cell Lymphoma -- Burkitt and Burkitt-Like Lymphoma -- Primary Effusion Lymphoma -- AIDS-related Central Nervous System Lymphoma -- Plasmablastic and Other Lymphomas -- Hodkin Lymphoma -- Multicentric Castelman Disease -- Cervical Cancer -- Anal Cancer -- Other HPV-Associated Cancers -- Lung Cancer in HIV Infection -- Hepattocellular Carcinoma in HIV-positive Patients -- Merkel Cell Carcinoma and Other HIV-associated Skin Cancers -- Conjuctival Carcinoma -- Malignancies in Children with HIV Infection -- cART and Supportive Care -- Stem Cell Transplantation. 330 $aThe association between AIDS and cancer was recognized from the beginning ofthe AIDS epidemic, when the appearance of Kaposi sarcoma in a cluster of youngmen was one of the first signs of this new disease. It was soon recognized that AIDSpatients are prone to develop a number of ?AIDS-defining? cancers: Kaposi sarcoma,lymphoma, and cervical cancer. The development of effective combination anti-HIVtherapy starting around 1996 converted AIDS from a death sentence to a manageabledisease and led to dramatic shifts in the epidemic. As this therapy was able to improveimmune function in patients, the incidence of most ?AIDS-defining? cancers decreased.There is a misconception, however, that AIDS has gone away. In fact, as AIDS patientsare living longer, the number of AIDS patients has more than doubled in the UnitedStates since 1996, and the AIDS population overall has increased in age. Also, as AIDSpatients are less likely to die of other complications, cancer is coming to the forefront as one of the most common causes of death in regions where AIDS drugs are widelyavailable.Moreover, the three ?AIDS-defining? cancers are now taking a back seat toa number of other HIV-associated cancers, such as Hodgkin lymphoma, lung cancer,and anal cancer. In the developing world, AIDS-associated cancers are a major publichealth problem, and in some regions of sub-Saharan Africa, Kaposi sarcoma is themost common tumor in men. In recent years, there has been a vast increase in our understanding of HIV-associatedcancers. We now know, for example, that most are caused by other viruses and thatthe main role of HIV and immunodeficiency is to provide a supportive environmentfor the viruses to multiply and for the cancers to develop. But there remain a numberof unanswered questions and a need for improved prevention and therapy. In the 28chapters of this book, written by some of the most renowned experts in this field, wepresent up-to-date information on the cancers associated with HIV infection. Thechapters cover the epidemiology of these cancers, as well as their pathogenesis, clinicalpresentation, and treatment. Dr. Robert Yarchoanis the Director of the Office of HIV and AIDS Malignancy andChief of the HIV and AIDS Malignancy Branch in the National Cancer Institute. Heplayed a major role in developing the first AIDS drugs. His research is now focused onAIDS-related cancers, especially Kaposi sarcoma and other cancers caused by Kaposisarcoma-associated herpesvirus. 606 $aImmunology 606 $aVirology 606 $aInfectious diseases 606 $aOncology   606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aVirology$3https://scigraph.springernature.com/ontologies/product-market-codes/B22003 606 $aInfectious Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33096 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 615 0$aImmunology. 615 0$aVirology. 615 0$aInfectious diseases. 615 0$aOncology  . 615 14$aImmunology. 615 24$aVirology. 615 24$aInfectious Diseases. 615 24$aOncology. 676 $a616.9792 702 $aYarchoan$b Robert$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298327103321 996 $aCancers in People with HIV and AIDS$92539459 997 $aUNINA