LEADER 04880nam 22007215 450 001 9910298326003321 005 20200705003648.0 010 $a3-319-04843-0 024 7 $a10.1007/978-3-319-04843-7 035 $a(CKB)3710000000130078 035 $a(EBL)1782191 035 $a(SSID)ssj0001268752 035 $a(PQKBManifestationID)11698066 035 $a(PQKBTitleCode)TC0001268752 035 $a(PQKBWorkID)11266302 035 $a(PQKB)10680730 035 $a(MiAaPQ)EBC1782191 035 $a(DE-He213)978-3-319-04843-7 035 $a(PPN)179766996 035 $a(EXLCZ)993710000000130078 100 $a20140612d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCurrent Advances in Osteosarcoma /$fedited by Eugenie S. Kleinerman, M.D 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (357 p.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v804 300 $aDescription based upon print version of record. 311 $a1-322-13422-7 311 $a3-319-04842-2 320 $aIncludes bibliographical references and index. 327 $aHistorical Perspective on the Introduction and Use of Chemotherapy for the Treatment of Osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: Not Just the Usual Suspects -- Understanding the Role of Notch in Osteosarcoma -- Developmental Pathways Highjacked by Osteosarcoma -- MicroRNAs in Osteosarcomagenesis -- RECQ DNA Helicases and Osteosarcoma -- Autophagy in Osteosarcoma -- HER-2 Involvement in Osteosarcoma -- Role of Ezrin in Osteosarcoma Metastasis -- Participation of the Fas/FasL Signaling Pathway and the Lung Microenvironment in the Development of Osteosarcoma Lung Metastases -- Zebrafish as a Model for Human Osteosarcoma -- Using Canine Osteosarcoma as a Model to Assess Efficacy of Novel Therapies: Can Old Dogs Teach Us New Tricks? -- Oncolytic Viruses for Potential Osteosarcoma Therapy -- IL-11R?: A Novel Target for the Treatment of Osteosarcoma -- Bone-seeking Radiopharmaceuticals as Targeted Agents of Osteosarcoma: Samarium-153-EDTMP and Radium-223 -- Muramyl Tripeptide-phophatidyl Ethanolamine Encapsulated in Lipomes (L-MTP-PE) in the Treatment of Osteosarcoma -- Genetically Modified T-cell Therapy for Osteosarcoma -- Natural Killer Cells for Osteosarcoma. 330 $aCurrent Advances in Osteosarcoma summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in this field over the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and is the most common histological form of bone cancer. Osteosarcoma accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. In order to improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. This volume will provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v804 606 $aCancer$xResearch 606 $aMedical microbiology 606 $aCytology 606 $aPediatrics 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aPediatrics$3https://scigraph.springernature.com/ontologies/product-market-codes/H49006 615 0$aCancer$xResearch. 615 0$aMedical microbiology. 615 0$aCytology. 615 0$aPediatrics. 615 14$aCancer Research. 615 24$aMedical Microbiology. 615 24$aCell Biology. 615 24$aPediatrics. 676 $a616.9940072 702 $aKleinerman$b M.D., Eugenie S$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298326003321 996 $aCurrent Advances in Osteosarcoma$92139472 997 $aUNINA