LEADER 04833nam 22006495 450 001 9910298325303321 005 20200706043622.0 010 $a3-319-08894-7 024 7 $a10.1007/978-3-319-08894-5 035 $a(CKB)3710000000244745 035 $a(EBL)1968506 035 $a(OCoLC)891652081 035 $a(SSID)ssj0001353634 035 $a(PQKBManifestationID)11733430 035 $a(PQKBTitleCode)TC0001353634 035 $a(PQKBWorkID)11315816 035 $a(PQKB)11410912 035 $a(MiAaPQ)EBC1968506 035 $a(DE-He213)978-3-319-08894-5 035 $a(PPN)181349310 035 $a(EXLCZ)993710000000244745 100 $a20140918d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aGlutamate and ATP at the Interface of Metabolism and Signaling in the Brain /$fedited by Vladimir Parpura, Arne Schousboe, Alexei Verkhratsky 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (275 p.) 225 1 $aAdvances in Neurobiology,$x2190-5215 ;$v11 300 $aDescription based upon print version of record. 311 $a3-319-08893-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $a1. Glutamate and ATP: The Crossroads of Signaling and Metabolism in the Brain -- 2. Glutamate Metabolism in the Brain Focusing on Astrocytes -- 3. Glycogenolysis and Purinergic Signaling -- 4. Purinergic and Glutamatergic Receptors on Astroglia -- 5. Regulated Exocytosis in Astrocytes Is as Slow as the Metabolic Availability of Gliotransmitters: Focus on Glutamate and ATP -- 6. Adenosine and Glutamate in Neuroglial Interaction: Implications for Circadian Disorders and Alcoholism -- 7. Purinergic Receptor Stimulation Decreases Ischemic Brain Damage By Energizing Astrocyte Mitochondria -- 8. Excitotoxicity and Mitochondrial Dysfunction Underlie Age-dependent Ischemic White Matter Injury -- 9. Role of Astrocytes in Delayed Neuronal Death: GLT-1 and its Novel Regulation by MicroRNAs -- 10. Ca2+ Signaling in Astrocytes and its Role in Ischemic Stroke -- 11. Pathological Potential of Astroglial Purinergic Receptors. 330 $aATP was naturally selected very early on as the main source of biological energy, and thus became an indispensable feature of life on the Earth. This was a critical evolutionary choice because it shaped enzymatic systems to utilize ATP in energy-dependent reactions and necessitated an appearance of the universal intracellular signaling system based on calcium ions; keeping cytosolic Ca2+ extremely low became vitally important, since otherwise insoluble Ca2+-phosphates would preclude the cell energetics. Thus, all living cells on the Earth, beginning from the most primitive ones, had high cytosolic concentrations of ATP and there is little surprise that ATP was soon utilized by nature for another fundamental function of sending information from one living cell to another. In summary, ATP acts as the main energy source and is pivotal for numerous signaling cascades both inside (by fueling various transport systems and donating phosphate groups) and between the cells (by chemical transmission). Similarly, glutamate acts as an important molecule for both intercellular signaling through glutamatergic transmission and cell energetics by contributing to ATP production. In this collection of chapters, written by the leading experts in the fields of cell metabolism and energetics, intracellular signaling and neurotransmission, we covered various aspects of the interfacing between these two fundamental molecules. This book will be particularly useful for researchers, students, physicians and psychotherapists working in the field of neurobiology, neurology and psychiatry. 410 0$aAdvances in Neurobiology,$x2190-5215 ;$v11 606 $aNeurosciences 606 $aNeurobiology 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aNeurobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L25066 615 0$aNeurosciences. 615 0$aNeurobiology. 615 14$aNeurosciences. 615 24$aNeurobiology. 676 $a572.65 702 $aParpura$b Vladimir$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSchousboe$b Arne$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aVerkhratsky$b Alexei$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298325303321 996 $aGlutamate and ATP at the Interface of Metabolism and Signaling in the Brain$92537241 997 $aUNINA