LEADER 05170nam 22007575 450 001 9910298321003321 005 20200630213752.0 010 $a94-017-8765-4 024 7 $a10.1007/978-94-017-8765-9 035 $a(CKB)3710000000095094 035 $a(EBL)1698417 035 $a(OCoLC)876368981 035 $a(SSID)ssj0001185935 035 $a(PQKBManifestationID)11672126 035 $a(PQKBTitleCode)TC0001185935 035 $a(PQKBWorkID)11212513 035 $a(PQKB)10338761 035 $a(MiAaPQ)EBC1698417 035 $a(DE-He213)978-94-017-8765-9 035 $a(PPN)17782218X 035 $a(EXLCZ)993710000000095094 100 $a20140331d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMFG-E8 and Inflammation /$fedited by Ping Wang 205 $a1st ed. 2014. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2014. 215 $a1 online resource (209 p.) 300 $aDescription based upon print version of record. 311 $a94-017-8764-6 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $a""Preface""; ""About the Editor""; ""Contents""; ""Contributors""; ""Chapter 1: MFG-E8: Origin, Structure, Expression, Functions and Regulation""; ""1 Origin, Primary Structure and Molecular Evolution""; ""2 Glycosylation""; ""3 Domain Structure and Molecular Functions""; ""3.1 The EGF-Like Domain with RGD Motif""; ""3.2 The F5/8-type C Domains""; ""3.3 Medin Peptide and Amyloid""; ""3.4 Binding with Extracellular Matrix""; ""3.5 P/T-Rich Domain of Murine MFG-E8""; ""4 Gene Expression""; ""4.1 Expression Profiling by Genomic Studies""; ""4.2 Regulation of Gene Expression"" 327 $a""1.2 a???Eat-Mea??? and a???Dona???t Eat-Mea??? Signals"" 330 $aAfter the discovery of milk fat globule-epidermal growth factor-factor 8 (MFG-E8) about two decades ago, a new era of delineating its potential beneficial role in several inflammatory diseases has begun to spout from the bench to translational research.  In MFG-E8 and Inflammation, the editor and contributors have gathered a remarkable collection covering novel discoveries on the rapidly growing field of MFG-E8 and Inflammation which includes not only the findings from their individual lobotomies, but also from a host of pioneering researchers of this field. MFG-E8 and Inflammation starts by describing the origin, structure, expression, functions and regulation of MFG-E8, and then on continues thoughtfully exploring its potentiality as a marker for apoptotic, stressed and activated cells.  The topics cover the cellular and physiological function of MFG-E8, especially its role in efficient phagocytosis of apoptotic cells, intestinal barrier function, blood cell homeostasis and coagulation, and in the maintenance of the intact vascular system.  The role of MFG-E8 in macrophages, neutrophils, lymphocytes, dendritic cells, platelets, as well as non-hematopoietic cells is adequately described in the book.  The chapters also contain several lucid discussions on the recent discoveries of the roles of MFG-E8 in the autoimmune diseases, sepsis, tissue ischemia-reperfusion, hemorrhage, inflammatory bowel disease, acute lung injury, asthma, lung fibrosis, stroke, prion disease and Alzheimer?s disease with the potential focus on elucidating novel mechanistic pathways. MFG-E8 and Inflammation is an indispensable resource for scientists and clinical researchers working on fundamental or applied aspects of MFG-E8 pathobiology.  This book explores, dissects and reviews several noteworthy findings and striking future perspectives which not only rewrite the disease pathophysiology, but also update our understanding towards attaining novel therapeutic potentials against various inflammatory diseases.       . 606 $aCancer research 606 $aImmunology 606 $aCell biology 606 $aPathology 606 $aMedicine 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 615 0$aCancer research. 615 0$aImmunology. 615 0$aCell biology. 615 0$aPathology. 615 0$aMedicine. 615 14$aCancer Research. 615 24$aImmunology. 615 24$aCell Biology. 615 24$aPathology. 615 24$aBiomedicine, general. 676 $a616.0473 676 $a616.97 676 $a616.97/8 676 $a616.978 702 $aWang$b Ping$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298321003321 996 $aMFG-E8 and Inflammation$92537237 997 $aUNINA