LEADER 05421nam 22007095 450 001 9910298321003321 005 20251007065916.0 010 $a9401787654 024 7 $a10.1007/978-94-017-8765-9 035 $a(CKB)3710000000095094 035 $a(EBL)1698417 035 $a(OCoLC)876368981 035 $a(SSID)ssj0001185935 035 $a(PQKBManifestationID)11672126 035 $a(PQKBTitleCode)TC0001185935 035 $a(PQKBWorkID)11212513 035 $a(PQKB)10338761 035 $a(MiAaPQ)EBC1698417 035 $a(DE-He213)978-94-017-8765-9 035 $a(PPN)17782218X 035 $a(EXLCZ)993710000000095094 100 $a20140331d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMFG-E8 and Inflammation /$fedited by Ping Wang 205 $a1st ed. 2014. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2014. 215 $a1 online resource (209 p.) 300 $aDescription based upon print version of record. 311 08$a9401787646 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $tMFG-E8: Origin, Structure, Expression, Functions and Regulation /$rKenzi Oshima, Takehiko Yasueda, Shunsuke Nishio, Tsukasa Matsuda --$tMFG-E8 as a Marker for Apoptotic, Stressed and Activated Cells /$rKristine Blans, Jan Trige Rasmussen --$tRole of MFG-E8 in Protection of Intestinal Epithelial Barrier Function and Attenuation of Intestinal Inflammation /$rSuhail Akhtar, Xiao Wang, Heng-Fu Bu, Xiao-Di Tan --$tMFG-E8 in the Blood Cell Homeostasis and Coagulation /$rSwapan Kumar Dasgupta, Perumal Thiagarajan --$tMFG-E8 in the Vascular System /$rXuan Li, Nicolas Deroide, Ziad Mallat --$tAutoimmune Diseases and the Role of MFG-E8 /$rRikinari Hanayama --$tNovel Therapeutic for Systemic Inflammation: Role of MFG-E8 /$rAsha Jacob, Ping Wang --$tAnti-Inflammatory Role of MFG-E8 in the Intestinal Tract /$rShunji Ishihara, Ryusaku Kusunoki, Yoshikazu Kinoshita --$tMFG-E8 and Acute Lung Injury /$rMonowar Aziz, Ping Wang --$tRole of MFG-E8 in the Brain /$rMonowar Aziz, Ping Wang. 330 $aAfter the discovery of milk fat globule-epidermal growth factor-factor 8 (MFG-E8) about two decades ago, a new era of delineating its potential beneficial role in several inflammatory diseases has begun to spout from the bench to translational research.  In MFG-E8 and Inflammation, the editor and contributors have gathered a remarkable collection covering novel discoveries on the rapidly growing field of MFG-E8 and Inflammation which includes not only the findings from their individual lobotomies, but also from a host of pioneering researchers of this field. MFG-E8 and Inflammation starts by describing the origin, structure, expression, functions and regulation of MFG-E8, and then on continues thoughtfully exploring its potentiality as a marker for apoptotic, stressed and activated cells.  The topics cover the cellular and physiological function of MFG-E8, especially its role in efficient phagocytosis of apoptotic cells, intestinal barrier function, blood cell homeostasis and coagulation, and in the maintenance of the intact vascular system.  The role of MFG-E8 in macrophages, neutrophils, lymphocytes, dendritic cells, platelets, as well as non-hematopoietic cells is adequately described in the book.  The chapters also contain several lucid discussions on the recent discoveries of the roles of MFG-E8 in the autoimmune diseases, sepsis, tissue ischemia-reperfusion, hemorrhage, inflammatory bowel disease, acute lung injury, asthma, lung fibrosis, stroke, prion disease and Alzheimer?s disease with the potential focus on elucidating novel mechanistic pathways. MFG-E8 and Inflammation is an indispensable resource for scientists and clinical researchers working on fundamental or applied aspects of MFG-E8 pathobiology.  This book explores, dissects and reviews several noteworthy findings and striking future perspectives which not only rewrite the disease pathophysiology, but also update our understanding towards attaining novel therapeutic potentials against various inflammatory diseases.       . 606 $aMilkfat 606 $aInflammation 606 $aPathology 606 $aInflammation$3(DNLM)D007249 606 $aPathology$3(DNLM)D010336 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 615 0$aMilkfat. 615 0$aInflammation. 615 0$aPathology. 615 2$aInflammation. 615 2$aPathology. 615 14$aCancer Research. 615 24$aImmunology. 615 24$aCell Biology. 615 24$aPathology. 615 24$aBiomedicine, general. 676 $a637.14 702 $aWang$b Ping$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298321003321 996 $aMFG-E8 and Inflammation$92537237 997 $aUNINA