LEADER 04279nam 22006855 450 001 9910298319603321 005 20200706130509.0 010 $a3-642-45106-3 024 7 $a10.1007/978-3-642-45106-5 035 $a(CKB)3710000000095042 035 $a(EBL)1697981 035 $a(OCoLC)881166051 035 $a(SSID)ssj0001185951 035 $a(PQKBManifestationID)11674169 035 $a(PQKBTitleCode)TC0001185951 035 $a(PQKBWorkID)11219661 035 $a(PQKB)11228286 035 $a(MiAaPQ)EBC1697981 035 $a(DE-He213)978-3-642-45106-5 035 $a(PPN)177825219 035 $a(EXLCZ)993710000000095042 100 $a20140325d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aNeurotrophic Factors /$fedited by Gary R. Lewin, Bruce D. Carter 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (514 p.) 225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v220 300 $aDescription based upon print version of record. 311 $a3-642-45105-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aThe Neurotrophin Family: NGF, BDNF, NT3 and NT4 -- Deciphering Proneurotrophin Actions -- Spatio-Temporal Intracellular Dynamics of Neurotrophins and Their Receptors. Implications for Neurotrophin Signaling and Neuronal Function -- Neurotrophins: Transcription and Translation -- Neurotrophin Receptors: Trk Receptors -- The Biological Functions and Signaling Mechanisms of the p75 Neurotrophin Receptor -- Sortilins in Neurotrophic Factor Signaling -- The Biology of Neurotrophins: Neurotrophins in the Regulation of Cellular Survival and Death -- BDNF and Synaptic Plasticity, Cognitive Function and Dysfunction -- Nerve Growth Factor and Nociception: From Experimental Embryology to New Analgesic Therapy -- Neurotrophins and the Regulation of Energy Balance and Body Weight -- The Biology of Neurotrophins: Cardiovascular Function -- Neurotrophin signalling and transcription programs interactions in the development of somatosensory neurons -- Neurotrophins in Pathological Conditions: Huntington?s Disease -- Motoneuron Disease -- Neurotrophic Factors in Spinal Cord Injury -- Neurotrophins and Psychiatric Disorders -- Brain Derived Neurotrophic Factor and Rett Syndrome -- Modulation of Neurotrophin Signaling by Monoclonal Antibodies. 330 $aThis book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington?s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles. 410 0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v220 606 $aPharmacology 606 $aMolecular biology 606 $aNeurosciences 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 615 0$aPharmacology. 615 0$aMolecular biology. 615 0$aNeurosciences. 615 14$aPharmacology/Toxicology. 615 24$aMolecular Medicine. 615 24$aNeurosciences. 676 $a573.8536 702 $aLewin$b Gary R$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCarter$b Bruce D$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298319603321 996 $aNeurotrophic factors$91078370 997 $aUNINA