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024 7 $a10.1007/978-3-642-40591-4
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100   $a20131022d2014      u|             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aMolecular Mechanisms in Legionella Pathogenesis$b[electronic resource] /$fedited by Hubert Hilbi
205   $a1st ed. 2014.
210  1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014.
215   $a1 online resource (297 p.)
225 1 $aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v376
300   $aDescription based upon print version of record.
311   $a3-642-40590-8 
320   $aIncludes bibliographical references and index.
327   $aFrom amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts -- The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors -- Facets of small RNA-mediated regulation in Legionella pneumophila -- Type II secretion and Legionella virulence -- Effector translocation by the Legionella Icm/Dot type IV secretion system -- Modulation of small GTPases by Legionella -- Host lipidation: A mechanism for spatial regulation of Legionella effectors -- Phosphoinositides and the Legionella pathogen vacuole -- Legionella phospholipases implicated in virulence -- Cytotoxic glucosyltransferases of Legionella pneumophila -- Modulation of the ubiquitination machinery by Legionella -- Host signal transduction and protein kinases implicated in Legionella infection -- Mouse models of Legionnaires´ disease.
330   $aLegionnaires? disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
410  0$aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v376
606   $aMedical microbiology
606   $aInfectious diseases
606   $aMolecular biology
606   $aImmunology
606   $aBacteriology
606   $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003
606   $aInfectious Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33096
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
606   $aBacteriology$3https://scigraph.springernature.com/ontologies/product-market-codes/L23012
615  0$aMedical microbiology.
615  0$aInfectious diseases.
615  0$aMolecular biology.
615  0$aImmunology.
615  0$aBacteriology.
615 14$aMedical Microbiology.
615 24$aInfectious Diseases.
615 24$aMolecular Medicine.
615 24$aImmunology.
615 24$aBacteriology.
676   $a616.2
676   $a616.2/4101
676   $a616.241
676   $a616.24101
702   $aHilbi$b Hubert$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298318703321
996   $aMolecular Mechanisms in Legionella Pathogenesis$92512246
997   $aUNINA