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010   $a3-319-05026-5
024 7 $a10.1007/978-3-319-05026-3
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035   $a(EBL)1698181
035   $a(OCoLC)881166130
035   $a(SSID)ssj0001185978
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035   $a(PQKBTitleCode)TC0001185978
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035   $a(MiAaPQ)EBC1698181
035   $a(DE-He213)978-3-319-05026-3
035   $a(PPN)177823976
035   $a(EXLCZ)993710000000095000
100   $a20140327d2014      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aSCF and APC E3 Ubiquitin Ligases in Tumorigenesis /$fby Hiroyuki Inuzuka, Wenyi Wei
205   $a1st ed. 2014.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014.
215   $a1 online resource (119 p.)
225 1 $aSpringerBriefs in Cancer Research,$x2194-1173
300   $aDescription based upon print version of record.
311   $a3-319-05025-7 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $a1. Introduction -- 2. The Fbxw subclass of SCF E3 ubiquitin Ligases -- 3. The FbxL subclass of SCF E3 ubiquitin Ligases -- 4. The Fbxo subclass of SCF E3 ubiquitin Ligases -- 5. APC/Cdc20 and APC/Cdh1 E3 ubiquitin Ligases -- 6. Conclusions and Future Perspectives.
330   $aThis SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.
410  0$aSpringerBriefs in Cancer Research,$x2194-1173
606   $aCancer research
606   $aCell cycle
606   $aProteins 
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aCell Cycle Analysis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16030
606   $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050
615  0$aCancer research.
615  0$aCell cycle.
615  0$aProteins .
615 14$aCancer Research.
615 24$aCell Cycle Analysis.
615 24$aProtein Structure.
676   $a616.994071
700   $aInuzuka$b Hiroyuki$4aut$4http://id.loc.gov/vocabulary/relators/aut$01058878
702   $aWei$b Wenyi$4aut$4http://id.loc.gov/vocabulary/relators/aut
906   $aBOOK
912   $a9910298315403321
996   $aSCF and APC E3 Ubiquitin Ligases in Tumorigenesis$92503018
997   $aUNINA