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005 20200705013420.0
010   $a1-4939-0509-0
024 7 $a10.1007/978-1-4939-0509-6
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035   $a(EBL)1697109
035   $a(OCoLC)881165649
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035   $a(DE-He213)978-1-4939-0509-6
035   $a(PPN)177822104
035   $a(EXLCZ)993710000000094963
100   $a20140328d2014      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aPrimary Aldosteronism $eMolecular Genetics, Endocrinology, and Translational Medicine /$fedited by Per Hellman
205   $a1st ed. 2014.
210  1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014.
215   $a1 online resource (242 p.)
300   $aDescription based upon print version of record.
311   $a1-4939-0508-2 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $aIntroduction -- Primary Aldosteronism: Molecular Mechanisms and Diagnosis -- Epidemiology and need for screening -- Low renin hypertension -- Molecular derangements in sporadic primary aldosteronism -- From genetic abnormalities to pathophysiological mechanisms -- Familial hyperaldosteronism type I -- Familial hyperaldosteronism type II -- Familial hyperaldosteronism type III -- The Aldosterone-renin ratio ? role and problems -- Confirmatory testing for Primary Aldosteronism -- Radiological imaging of adrenocortical tumors -- Aldosterone and cardiovascular disease -- Quality of life aspects of primary aldosteronism -- Medical treatment of primary aldosteronism -- Surgical treatment of primary aldosteronism -- Index.
330   $aPrimary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene ? KCNJ5 ? in about 40% of PA with adenoma. Chapters in this book include a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more.
606   $aHuman genetics
606   $aEndocrinology
606   $aMedicine
606   $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008
606   $aEndocrinology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33053
606   $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X
615  0$aHuman genetics.
615  0$aEndocrinology.
615  0$aMedicine.
615 14$aHuman Genetics.
615 24$aEndocrinology.
615 24$aBiomedicine, general.
676   $a599935
676   $a610
676   $a611.01816
676   $a616
702   $aHellman$b Per$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298313803321
996   $aPrimary Aldosteronism$92503015
997   $aUNINA