LEADER 05456nam 22006735 450 001 9910298311703321 005 20200707005835.0 010 $a3-319-05134-2 024 7 $a10.1007/978-3-319-05134-5 035 $a(CKB)3710000000105686 035 $a(EBL)1731029 035 $a(OCoLC)885122340 035 $a(SSID)ssj0001199636 035 $a(PQKBManifestationID)11806845 035 $a(PQKBTitleCode)TC0001199636 035 $a(PQKBWorkID)11214676 035 $a(PQKB)10806846 035 $a(MiAaPQ)EBC1731029 035 $a(DE-He213)978-3-319-05134-5 035 $a(PPN)178317845 035 $a(EXLCZ)993710000000105686 100 $a20140422d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMicroRNA Targeted Cancer Therapy /$fedited by Fazlul H. Sarkar 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (349 p.) 300 $aDescription based upon print version of record. 311 $a3-319-05133-4 320 $aIncludes bibliographical references and index. 327 $aPreface -- The therapeutic role of microRNAs in human gliomas -- miRNA expression and functions in glioma and glioma stem cells -- The role of miRNAs in lung cancer drug resistance and targeted therapy -- The Potential Role of MicroRNA-Based Therapy for Lung Cancer Stem Cells -- State of our knowledge on miRNA targeted therapy in Lung Cancer -- miRNA-based Ovarian Cancer Diagnosis and Therapy -- Application of microRNA in the treatment and diagnosis of cervical cancer -- Overcoming Drug Resistance in Colorectal Cancer by microRNAs -- MicroRNAs as novel targets in liver cancer- facing the clinical challenge -- MicroRNA based therapeutic strategies for cancer: Emphasis on advances in renal cell carcinoma -- Modulating microRNA expression for the therapy of pancreatic cancer -- MicroRNA targeted therapy for overcoming drug resistance, reversal of EMT and elimination of cancer stem cells in prostate and pancreatic cancer.- Modulation of deregulated miRNAs for targeted therapy in thyroid cancer -- miRNA-targeted therapies in the most prevalent pediatric solid tumors -- Targeting Immune System Through Targeting miRNA For Cancer Therapy.- miRNA regulation of DNA damage repair proteins in cancer cells: interplay of ATM, TRAIL and miRNA -- miRNA regulation of VEGF/VEGFR signaling -- Systems Biology Approaches in the Design of Effective miRNA-Targeted Therapeutics. Index. 330 $aSince the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes, and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs), and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book ?MicroRNA targeted Cancer therapy?, and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs. 606 $aCancer$xResearch 606 $aLife sciences 606 $aMedicine 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aScience, Humanities and Social Sciences, multidisciplinary$3https://scigraph.springernature.com/ontologies/product-market-codes/A11007 606 $aLife Sciences, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L00004 606 $aMedicine/Public Health, general$3https://scigraph.springernature.com/ontologies/product-market-codes/H00007 615 0$aCancer$xResearch. 615 0$aLife sciences. 615 0$aMedicine. 615 14$aCancer Research. 615 24$aScience, Humanities and Social Sciences, multidisciplinary. 615 24$aLife Sciences, general. 615 24$aMedicine/Public Health, general. 676 $a50 676 $a570 676 $a610 676 $a614.5999 702 $aSarkar$b Fazlul H$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298311703321 996 $aMicroRNA Targeted Cancer Therapy$92544729 997 $aUNINA