LEADER 05740nam 22007095 450 001 9910298309903321 005 20230810211708.0 010 $a3-642-54452-5 024 7 $a10.1007/978-3-642-54452-1 035 $a(CKB)3710000000105676 035 $a(EBL)1731267 035 $a(OCoLC)884014051 035 $a(SSID)ssj0001199622 035 $a(PQKBManifestationID)11690855 035 $a(PQKBTitleCode)TC0001199622 035 $a(PQKBWorkID)11203359 035 $a(PQKB)10111097 035 $a(MiAaPQ)EBC1731267 035 $a(DE-He213)978-3-642-54452-1 035 $a(PPN)178322040 035 $a(EXLCZ)993710000000105676 100 $a20140422d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aChemical Biology of Nucleic Acids $eFundamentals and Clinical Applications /$fedited by Volker A. Erdmann, Wojciech T. Markiewicz, Jan Barciszewski 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (599 p.) 225 1 $aRNA Technologies,$x2197-9758 300 $aDescription based upon print version of record. 311 $a3-642-54451-7 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aRNA as Major Components in Chemical Evolvable Systems -- How the Early Genetic Code Was Established? - Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems -- Isomerization of RNA Phosphodiester Linkages -- Effects of Ionic Liquid and Liposomes on the Structure, Stability and Function of Nucleic Acids -- Oxidative Damage on RNA Nucleobases -- Use of FRET to Study Dynamics of DNA Replication -- Design, Characterization and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds -- Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies -- Flexible Nucleobase Analogues. Novel Tools for Exploring the Nucleic Acids -- Sequence Selective Recognition of Double-Stranded RNA -- Determining Transient Nucleic Acid Structures by NMR -- Diastereomer-Specific Repertoire of 7?R- or 7?S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physicochemical and Enzymological Properties -- Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms -- Progress in Chemically Modified Nucleic Acid Aptamers -- Aptamers as Molecular Smugglers -- Biochemical Aspects of Subcellular RNA Transport and Localization -- Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications -- Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology -- Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges -- Interaction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression -- Site Directed Spin Labelling of RNA for Distance Measurements by EPR -- Chemo-Enzymatic Strategies to Modify RNA in vitro or in Living Cells -- Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches -- DNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics -- Peptides Targeting G-Quadruplex Structures -- Synthesis of Site-Specifically Modified Long-Mer RNAs -- Synthesis and Exon-Skipping Activity of Chemically-Modified RNAs -- mRNA and snRNA Cap Analogs: Synthesis and Applications -- Innovative Chemistry for Synthesis of Regular RNA, 5?-Triphosphate RNA or 5?-Capped RNA. 330 $aThis volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research. 410 0$aRNA Technologies,$x2197-9758 606 $aBiomaterials 606 $aNucleic acids 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aMedical genetics 606 $aNucleic Acid 606 $aBiomedical Research 606 $aMedical Genetics 615 0$aBiomaterials. 615 0$aNucleic acids. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aMedical genetics. 615 14$aNucleic Acid. 615 24$aBiomedical Research. 615 24$aMedical Genetics. 676 $a572.8 702 $aErdmann$b Volker A$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMarkiewicz$b Wojciech T$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBarciszewski$b Jan$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298309903321 996 $aChemical Biology of Nucleic Acids$92498377 997 $aUNINA