LEADER 04605nam 22007695 450 001 9910298307003321 005 20200701162936.0 010 $a3-642-41588-1 024 7 $a10.1007/978-3-642-41588-3 035 $a(CKB)2560000000148992 035 $a(EBL)1698463 035 $a(OCoLC)881161961 035 $a(SSID)ssj0001199652 035 $a(PQKBManifestationID)11703443 035 $a(PQKBTitleCode)TC0001199652 035 $a(PQKBWorkID)11204736 035 $a(PQKB)11724111 035 $a(MiAaPQ)EBC1698463 035 $a(DE-He213)978-3-642-41588-3 035 $a(PPN)178321028 035 $a(EXLCZ)992560000000148992 100 $a20140415d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aVoltage Gated Sodium Channels /$fedited by Peter C. Ruben 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (295 p.) 225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v221 300 $aDescription based upon print version of record. 311 $a3-642-41587-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aOverview: biophysical properties and structure of sodium channels.- The voltage sensor module in sodium channels -- Slow inactivation of Na+ channels -- Regulation/modulation of sensory neuron sodium channels -- Ubiquitylation of voltage-gated sodium channels -- Probing gating mechanisms of sodium channel using pore blockers -- Animal toxins influence voltage-gated sodium channel function -- Voltage-sensor trapping toxins: Iso form-specific ligands for sodium channels -- Pharmacological insights and quirks of bacterial sodium channels -- The role of non-pore-forming ? subunits in physiology and pathophysiology of voltage-gated sodium channels -- The role of late INa in development of cardiac arrhythmias -- Proton modulation of cardiac INa: A potential arrhythmogenic trigger -- Altered sodium channel gating as molecular basis for pain: Contribution of activation, inactivation and resurgent currents. . 330 $aA number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied. 410 0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v221 606 $aPharmacology 606 $aNeurosciences 606 $aCardiology 606 $aCell membranes  606 $aProteins  606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037 606 $aMembrane Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16050 606 $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050 615 0$aPharmacology. 615 0$aNeurosciences. 615 0$aCardiology. 615 0$aCell membranes . 615 0$aProteins . 615 14$aPharmacology/Toxicology. 615 24$aNeurosciences. 615 24$aCardiology. 615 24$aMembrane Biology. 615 24$aProtein Structure. 676 $a612.014 702 $aRuben$b Peter C$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298307003321 996 $aVoltage gated sodium channels$91078369 997 $aUNINA