LEADER 05355nam 22007215 450 001 9910298306803321 005 20200706201805.0 010 $a3-319-01336-X 024 7 $a10.1007/978-3-319-01336-7 035 $a(CKB)3710000000025212 035 $a(EBL)1466390 035 $a(OCoLC)876508812 035 $a(SSID)ssj0001004926 035 $a(PQKBManifestationID)11573911 035 $a(PQKBTitleCode)TC0001004926 035 $a(PQKBWorkID)11051367 035 $a(PQKB)11017606 035 $a(MiAaPQ)EBC1466390 035 $a(DE-He213)978-3-319-01336-7 035 $a(PPN)172423805 035 $a(EXLCZ)993710000000025212 100 $a20130930d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSystems Biology $eFunctional Strategies of Living Organisms /$fby Leszek Konieczny, Irena Roterman-Konieczna, Pawe? Spólnik 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (214 p.) 300 $aDescription based upon print version of record. 311 $a3-319-01335-1 320 $aIncludes bibliographical references and index. 327 $aThe Structure and Function of Living Organisms -- General physiochemical properties of biological structures -- Self-organization -- Hypothesis - Protein folding simulation hypothesis - late stage intermediate ? role of water -- Energy in Biology ? Demand and Use -- General principles of thermodynamics -- Biological energy sources ? synthesis of water -- ATP synthesis -- Photosynthesis -- Direct and indirect exploitation of energy sources -- Energy conversion efficiency in biological processes -- Entropic effects -- Energy requirements of organisms -- Information ? Its Role and Meaning in Organisms -- Information as a quantitative concept. - Reliability of information sources -- Types of information conveyed by DNA -- Information entropy and mechanisms assisting selection -- The role of information in interpreting pathological events -- Hypothesis - Protein folding early stage intermediate -- Regulation in Biological Systems -- The cell and the organism -- The principle and mechanism of automatic intracellular regulation -- Regulatory coupling between cells and organisms ? hierarchical properties of regulation -- Regulatory mechanisms on the organism level -- Basic principles of regulation in biology -- Regulation levels -- Hypothesis - Proteome construction hypothesis -- Interrelationships in Organized Biological Systems -- The need of mutual relations in biological systems -- Cooperation and coordination -- The characteristics of process coordination in individual cells and organisms -- Mutual relationship between cells and the organism ? activation and inhibition of enzymes (rapid effects) -- Mutual support between cells and the organism ? interdependence related to gene expression (slow effects) -- Specialization of cell interrelationships -- Hypothesis - The criteria of life. 330 $aThe objective of this book is to present the strategies employed by living organisms on a molecular level and to help understand the basics of Systems Biology. Its content is organized in a way to meet the exponential growth in the volume of biological knowledge, and the need for a multidisciplinary approach in the practice of teaching modern biology. For this reason, the whole material is divided into five chapters, each devoted to a fundamental concept: Structure-Function, Energy, Information, Regulation and Interrelationships. The book describes generic mechanisms which occur in biology and promotes a simulation-based approach to the subject of Systems Biology. The use of basic knowledge as the background for presenting biological problems obligates the teachers to deal with generalized phenomena comprising the ever increasing volume of teaching materials. This book is intended for biologists and is informative for specialists in the areas of computer science, robotics and engineering. 606 $aMedicine 606 $aSystems biology 606 $aCell biology 606 $aBioinformatics 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 606 $aSystems Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L15010 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aBioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15001 615 0$aMedicine. 615 0$aSystems biology. 615 0$aCell biology. 615 0$aBioinformatics. 615 14$aBiomedicine, general. 615 24$aSystems Biology. 615 24$aCell Biology. 615 24$aBioinformatics. 676 $a570 676 $a570.11 676 $a570285 676 $a571.6 700 $aKonieczny$b Leszek$4aut$4http://id.loc.gov/vocabulary/relators/aut$01058339 702 $aRoterman-Konieczna$b Irena$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aSpólnik$b Pawe?$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910298306803321 996 $aSystems Biology$92499309 997 $aUNINA