LEADER 04711nam 22006375 450 001 9910298306003321 005 20200704024744.0 010 $a94-007-7905-4 024 7 $a10.1007/978-94-007-7905-1 035 $a(CKB)3710000000078953 035 $a(DE-He213)978-94-007-7905-1 035 $a(SSID)ssj0001086359 035 $a(PQKBManifestationID)11613200 035 $a(PQKBTitleCode)TC0001086359 035 $a(PQKBWorkID)11056494 035 $a(PQKB)10804050 035 $a(MiAaPQ)EBC6310793 035 $a(MiAaPQ)EBC1591941 035 $a(Au-PeEL)EBL1591941 035 $a(CaPaEBR)ebr10983439 035 $a(OCoLC)922907543 035 $a(PPN)176130438 035 $a(EXLCZ)993710000000078953 100 $a20131208d2014 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMechanisms of Gene Regulation /$fby Carsten Carlberg, Ferdinand Molnár 205 $a1st ed. 2014. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2014. 215 $a1 online resource (XV, 210 p. 83 illus., 64 illus. in color.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a94-007-7904-6 320 $aIncludes bibliographical references. 327 $aOverview: What is gene expression? -- The impact of chromatin -- The basal transcriptional machinery -- Transcription factors -- Linking signal transduction and gene regulation -- Switching genes on and off at the example of nuclear receptors -- Mapping the genome -- Chromatin modifiers -- Genomic imprinting -- The epigenome -- Chromatin remodeling -- Chromatin architecture -- Regulatory RNA. 330 $aThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading from students of all the biomedical sciences in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor biding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule which states that ?a picture tells more than thousand words?. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories. 606 $aGene expression 606 $aProteins  606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050 615 0$aGene expression. 615 0$aProteins . 615 14$aGene Expression. 615 24$aProtein Structure. 676 $a572.865 700 $aCarlberg$b Carsten$4aut$4http://id.loc.gov/vocabulary/relators/aut$0849346 702 $aMolnár$b Ferdinand$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298306003321 996 $aMechanisms of Gene Regulation$92496674 997 $aUNINA