LEADER 03952nam 22006855 450 001 9910298301003321 005 20200630130445.0 010 $a3-642-45179-9 024 7 $a10.1007/978-3-642-45179-9 035 $a(CKB)3710000000078874 035 $a(EBL)1636657 035 $a(OCoLC)871224051 035 $a(SSID)ssj0001086165 035 $a(PQKBManifestationID)11668018 035 $a(PQKBTitleCode)TC0001086165 035 $a(PQKBWorkID)11056029 035 $a(PQKB)11210384 035 $a(MiAaPQ)EBC1636657 035 $a(DE-He213)978-3-642-45179-9 035 $a(PPN)176117857 035 $a(EXLCZ)993710000000078874 100 $a20131218d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCell Aging: Molecular Mechanisms and Implications for Disease /$fby Christian Behl, Christine Ziegler 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (113 p.) 225 1 $aSpringerBriefs in Molecular Medicine,$x2197-7925 300 $aDescription based upon print version of record. 311 $a3-642-45178-0 320 $aIncludes bibliographical references at the end of each chapters. 327 $aAging and cell aging: an introduction -- Cell cycle: the life cycle of a cell -- Theories and mechanisms of aging -- Selected age-related disorders. 330 $aAging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging ? some of which have been discussed for decades ? are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single ?perfect? theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer?s disease. 410 0$aSpringerBriefs in Molecular Medicine,$x2197-7925 606 $aMolecular biology 606 $aCytology 606 $aPathology 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X 615 0$aMolecular biology. 615 0$aCytology. 615 0$aPathology. 615 14$aMolecular Medicine. 615 24$aCell Biology. 615 24$aPathology. 676 $a571.6 700 $aBehl$b Christian$4aut$4http://id.loc.gov/vocabulary/relators/aut$01058337 702 $aZiegler$b Christine$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298301003321 996 $aCell Aging: Molecular Mechanisms and Implications for Disease$92499303 997 $aUNINA