LEADER 04757nam 22007935 450 001 9910298298203321 005 20250604101835.0 010 $a3-319-16850-9 024 7 $a10.1007/978-3-319-16850-0 035 $a(CKB)3710000000403945 035 $a(SSID)ssj0001500621 035 $a(PQKBManifestationID)11810729 035 $a(PQKBTitleCode)TC0001500621 035 $a(PQKBWorkID)11522402 035 $a(PQKB)10548052 035 $a(DE-He213)978-3-319-16850-0 035 $a(MiAaPQ)EBC6312364 035 $a(MiAaPQ)EBC5586930 035 $a(Au-PeEL)EBL5586930 035 $a(OCoLC)908250053 035 $a(PPN)185485979 035 $a(EXLCZ)993710000000403945 100 $a20150420d2015 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aBiomolecular Interfaces $eInteractions, Functions and Drug Design /$fby Ariel Fernández Stigliano 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (XIX, 372 p. 145 illus., 86 illus. in color.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a3-319-16849-5 327 $aThe Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology -- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water -- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches -- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface -- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation -- Evolution of Protein Structure Degradation and Lessons for the Drug Designer -- Chemical Functionality of the Aqueous Interface in Soluble Proteins -- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy -- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer -- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine -- Controlling Induced Folding Through Wrapping Drug Design -- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology -- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology -- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment -- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design -- Epilogue -- Appendix 1. Code for Dehydron Identification -- Appendix 2. Solutions of Problems. 330 $aThe book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering. 606 $aProteins 606 $aBiological transport 606 $aCell membranes 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aPharmaceutical chemistry 606 $aBiophysics 606 $aProtein Biochemistry 606 $aMembrane Trafficking 606 $aBiomedical Research 606 $aPharmaceutics 606 $aBiophysics 615 0$aProteins. 615 0$aBiological transport. 615 0$aCell membranes. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aPharmaceutical chemistry. 615 0$aBiophysics. 615 14$aProtein Biochemistry. 615 24$aMembrane Trafficking. 615 24$aBiomedical Research. 615 24$aPharmaceutics. 615 24$aBiophysics. 676 $a574.19283 700 $aFernández Stigliano$b Ariel$4aut$4http://id.loc.gov/vocabulary/relators/aut$01059878 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298298203321 996 $aBiomolecular Interfaces$92509313 997 $aUNINA