LEADER 04203nam 22006015 450 001 9910298297403321 005 20200702165212.0 010 $a1-4899-7558-6 024 7 $a10.1007/978-1-4899-7558-4 035 $a(CKB)3710000000375259 035 $a(EBL)1997870 035 $a(SSID)ssj0001465034 035 $a(PQKBManifestationID)11935151 035 $a(PQKBTitleCode)TC0001465034 035 $a(PQKBWorkID)11458340 035 $a(PQKB)11113997 035 $a(DE-He213)978-1-4899-7558-4 035 $a(MiAaPQ)EBC1997870 035 $z(PPN)258862793 035 $a(PPN)18489073X 035 $a(EXLCZ)993710000000375259 100 $a20150313d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aOral Mucosal Drug Delivery and Therapy /$fedited by Michael J. Rathbone, Sevda Senel, Indiran Pather 205 $a1st ed. 2015. 210 1$aNew York, NY :$cSpringer US :$cImprint: Springer,$d2015. 215 $a1 online resource (289 p.) 225 1 $aAdvances in Delivery Science and Technology,$x2192-6204 300 $aDescription based upon print version of record. 311 $a1-4899-7557-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $a1 Anatomy and Physiology of the Oral Mucosa -- 2 Design and Development of Oral Mucosal Drug Delivery Systems -- 3 Chemical Methods for Enhancing Oral Mucosal Delivery -- 4 Mucoadhesive Polymers as Enabling Excipients for Oral Mucosal Drug Delivery -- 5 Physical Methods for Enhancing Oral Mucosal Delivery: Sonophoresis, Iontophoresis and Electroporation -- 6 Characterization Methods for Oral Mucosal Drug Delivery -- 7 Design and Development of Systemic Oral Mucosal Drug Delivery Systems -- 8 Tablets and Other Solid Dosage Forms for Systemic Oral Mucosal Drug Delivery -- 9 Formulation of Delivery Systems for Photosensitisers Used in Oral Cavity Photodynamic Therapy -- 10 Medical devices for Oral Mucosal Applications -- 11 Pharmaceuticals for Oral Mucosal Drug Delivery:  Regulatory Considerations. 330 $aThis volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route for drug delivery and how they impact the design of oral mucosal drug delivery systems. It also provides a detailed description of current oral mucosal drug delivery technologies that overcome these challenges alongside research, development and assessment methods.   In 11 authoritative chapters, the book affords an in-depth evaluation of the major issues associated with this route of administration, namely the retention of the drug/product at the site of administration and increasing drug permeability through the oral mucosa.  The book provides insights into the in vitro and in vivo methods available to assess drug permeability and retention, offers solutions on how to improve the permeation of the drugs through the oral mucosa, and explores approaches to prolong drug/product retention at the site of administration. It also indicates future directions in research and product development. Oral Mucosal Drug Delivery and Therapy is a key resource for those wishing to extend their knowledge of this field. 410 0$aAdvances in Delivery Science and Technology,$x2192-6204 606 $aPharmaceutical technology 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 615 0$aPharmaceutical technology. 615 14$aPharmaceutical Sciences/Technology. 676 $a610.73 702 $aRathbone$b Michael J$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSenel$b Sevda$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aPather$b Indiran$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298297403321 996 $aOral Mucosal Drug Delivery and Therapy$92499298 997 $aUNINA