LEADER 07326nam 22007215 450 001 9910298297203321 005 20200702001545.0 010 $a3-319-17972-1 024 7 $a10.1007/978-3-319-17972-8 035 $a(CKB)3710000000402906 035 $a(EBL)2095903 035 $a(SSID)ssj0001500675 035 $a(PQKBManifestationID)11967968 035 $a(PQKBTitleCode)TC0001500675 035 $a(PQKBWorkID)11520517 035 $a(PQKB)11528171 035 $a(DE-He213)978-3-319-17972-8 035 $a(MiAaPQ)EBC2095903 035 $a(PPN)185488064 035 $a(EXLCZ)993710000000402906 100 $a20150425d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aResistance to Aromatase Inhibitors in Breast Cancer /$fedited by Alexey Larionov 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (298 p.) 225 1 $aResistance to Targeted Anti-Cancer Therapeutics,$x2196-5501 ;$v8 300 $aDescription based upon print version of record. 311 $a3-319-17971-3 320 $aIncludes bibliographical references and index. 327 $aPreface; Acknowledgments; Contents; 1 Clinical Use of Aromatase Inhibitors in Breast Cancer: History and Present ; Abstract ; Abbreviations; Introduction; From Beatson to Aromatase Inhibitors; Current Situation; Neo-Adjuvant Setting; Adjuvant Setting; Advanced Disease; Resistance to Aromatase Inhibition; Conclusion; References; 2 Structure, Regulation and Polymorphisms of the Aromatase Gene ; Abstract ; Abbreviations; Introduction: Tissue-Specific Expression of Human Aromatase; Structure of the Human Aromatase Gene; Expression of Aromatase in Breast Cancer Stroma 327 $aTranscriptional Regulation of the Aromatase Gene in Breast Cancer TissuesEpigenetic Regulation of Aromatase; Genetic Polymorphisms of the Human Aromatase Gene Associated with AI Response and Susceptibility to Breast Cancer; Post-transcriptional Regulation of Aromatase; Other Possible Factors that Affect Aromatase; Conclusion; References; 3 Structure, Function and Inhibition of Aromatase ; Abstract ; Abbreviations; Introduction; Crystal Structure of Human Placental Aromatase; Architecture of the Active Site; Structural Perspective on the Mechanism of Action; Membrane Integration 327 $aOligomerization of AromataseRoles of Critical Residues; Motion and Flexibility of the Aromatase Molecule; Aromatase Inhibitors: Recent Developments; Phosphorylation of Aromatase and Estrogen Signaling: The New Frontier; Concluding Remarks; References; 4 In Vivo Models of AI Resistance ; Abstract ; Abbreviations; Introduction; Carcinogen Induced Syngeneic Tumor Model; Xenograft Model Using the Nude Mouse; Intra-tumoral Aromatase Xenograft Model; Aromatase Inhibitors as First Line Agents; AI Resistance Models; Estrogen Deprivation Based Models; LTED Model; UMB-1Ca Model 327 $aLetrozole Resistance ModelTransplanted Tumors; Activation of Growth Factor Pathways; Other Models; Variations Between the Models of AI Resistance; Discrepancies Between Animal Models and Clinical Data; Conclusion; References; 5 Ineffective Inhibition of Aromatase: A Cause for AI Resistance? ; Abstract ; Abbreviations; Introduction; The Aromatase Enzyme and Estrogen Disposition in Postmenopausal Women; Plasma Estrogen Measurements in Relation to Treatment with Aromatase Inhibitors; Tracer Studies; Tissue Estrogen Levels; Conclusions; References 327 $a6 Understanding the New Biology of Estrogen-Induced Apoptosis and Its Application in Patient Care Abstract ; Abbreviations; Introduction; Selective Estrogen Receptor Modulators (SERMs); Contribution of SERM Resistance in Understanding Estrogen-Induced Apoptosis; Long-Term Estrogen Deprivation; Molecular Mechanisms of Estrogen-Induced Apoptosis; Estrogen-Induced Apoptosis: Clinical Translation Opportunities; Perspectives and Conclusions; References; 7 Ligand-Independent Signalling Through Estrogen Receptor Pathways in Breast Cancer ; Abstract ; Abbreviations; Introduction 327 $aBackground: Classical Ligand-Dependent Estrogen Receptor Signalling 330 $aThe book brings together current knowledge about molecular and clinical aspects of resistance to aromatase inhibitors (AIs). The topics and features include: The history of development and clinical role of aromatase inhibitors in breast cancer. The structure and function of aromatase gene and protein, including tissue-specific splicing and regulation of the gene, crystal structure of the enzyme, functioning of its active site and structural basis for development of new aromatase inhibitors. Experimental and pre-clinical models of resistance to aromatase inhibitors (including cell lines and xenografts) as well as methods and results of measuring oestrogen concentrations in blood and tumour tissue of breast cancer patients. Diversity of molecular mechanisms of AI resistance, including (i) ligand-independent signalling through oestrogen receptor pathway, (ii) hypersensitivity to low concentrations of oestrogens, (iii) crosstalk with non-endocrine signalling (including PI3K/mTOR, IGF, GDNF and Myc pathways), (iv) involvement of oestrogen-induced apoptosis and tissue microenvironment (including inflammatory immune cells and adipocytes) as well as (v) the role of epigenetic mechanisms and pioneering factors in ER signalling and AI resistance. Molecular markers and multi-gene signatures to predict response to AIs, clinical trials aimed at preventing or overcoming resistance by combining AIs with novel targeted agents (including AI combinations with HER2, EGFR, mTOR, PI3K, Akt, CDK4/6, FGFR, HDAC, IGF-1, Src, proteosome- and angiogenic- targeting agents). A review of the effects and clinical indications of aromatase inhibitors beyond breast cancer. Many of the chapters provide extensive historical overviews to connect current knowledge with the history and inner logic of the field. The authors? team includes world-leading experts, making the book an essential resource for scientists developing new treatments for breast cancer and for medics treating breast cancer patients with aromatase inhibitors. 410 0$aResistance to Targeted Anti-Cancer Therapeutics,$x2196-5501 ;$v8 606 $aCancer research 606 $aDrug resistance 606 $aMolecular biology 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aDrug Resistance$3https://scigraph.springernature.com/ontologies/product-market-codes/B16020 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 615 0$aCancer research. 615 0$aDrug resistance. 615 0$aMolecular biology. 615 14$aCancer Research. 615 24$aDrug Resistance. 615 24$aMolecular Medicine. 676 $a610 676 $a611.01816 676 $a614.5999 676 $a616.9041 702 $aLarionov$b Alexey$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298297203321 996 $aResistance to Aromatase Inhibitors in Breast Cancer$92505625 997 $aUNINA