LEADER 05811nam 22006735 450 001 9910298296903321 005 20250609111445.0 010 $a3-319-15811-2 024 7 $a10.1007/978-3-319-15811-2 035 $a(CKB)3710000000402905 035 $a(EBL)2094444 035 $a(SSID)ssj0001500663 035 $a(PQKBManifestationID)11866010 035 $a(PQKBTitleCode)TC0001500663 035 $a(PQKBWorkID)11523114 035 $a(PQKB)10995278 035 $a(DE-He213)978-3-319-15811-2 035 $a(MiAaPQ)EBC2094444 035 $a(PPN)18548557X 035 $a(MiAaPQ)EBC3110076 035 $a(EXLCZ)993710000000402905 100 $a20150425d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aNext Generation Sequencing in Cancer Research, Volume 2 $eFrom Basepairs to Bedsides /$fedited by Wei Wu, Hani Choudhry 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (500 p.) 300 $aDescription based upon print version of record. 311 08$a3-319-15810-4 320 $aIncludes bibliographical references and index. 327 $aSingle-cell next Generation Sequencing and Its Applications in Cancer Biology -- Utility of Next Generation Sequencing in Cancer Drug Development and Clinical Trials -- Next-Generation Sequencing in the Era of Cancer-Targeted Therapies: Towards the Personalised Medicine -- Mutational Similarities Across Cancers: Implications for Research, Diagnostics and Personalized Therapy Design -- Standardized Decision Support in NGS Reports of Somatic Cancer Variants -- Clinical Considerations in the Conduct of Cancer Next Generation Sequencing Testing and Genetic Counselling -- Next Generation Sequencing for Cancer Biomarker Discovery -- Validation and Implementation of Next Generation Sequencing Technologies in a Clinical Molecular Diagnostic Laboratory -- Next Generation Sequencing Technologies and Formalin Fixed Paraffin Embedded Tissue: Application to Clinical Cancer Research -- Applications of NGS to Screen FFPE Tumours for Detecting Fusion Transcripts -- Clinical Application of Next-Generation Sequencing of Formalin-Fixed Paraffin-Embedded Tumors -- ChIP-BS-Sequencing in Cancer Epigenomics -- Integrative Analysis Identifies Transcription Factor-DNA Methylation Relationships and Introduces New Avenues for Translating Cancer Epigenetics Into the Clinic -- Differential Methylation Analysis with Next-Generation Sequencing -- Performance Comparison and Data Analysis Strategies for MicroRNA Profiling in Cancer Research -- Small RNA Sequencing for Squamous Cell Carcinoma Research -- Exome Capture and Capturing Technologies in Cancer Research -- The Landscape of DNA Virus Associations Across Human Malignant Cancers -- Using Next Generation Sequencing to Reveal Patterns of Chromosomal Alterations in Oral Verrucous Carcinoma -- Vironomics: The Study of Viral Genomics in Human Cancer and Disease -- Molecular Typing of Lung Adenocarcinoma on Cytological Samples in the Next Generation Sequencing Era -- Whole Genome/Exome Sequencing in Acute Leukemia: From Research to Clinics -- Next Generation Sequencing Applications in Head and Neck Oncology -- CIC Mutation in Brain Tumor -- Isocitrate Dehydrogenase (IDH) Mutation in Gliomas -- Utilization of Multigene Panels in Hereditary Cancer Predisposition Testing. 330 $aNext Generation Sequencing in Cancer Research, Volume 2: From Basepairs to Bedsides, the second in the series ?Next Generation Sequencing Technology in Cancer Research?From Basepairs to Bedsides,? is designed to fill the gap between cancer genome research and clinical management of the individual cancer patient. The volume presents the principles of next generation sequencing (NGS) technologies and massively parallel DNA sequencing and their application of the whole genome sequences (WGS), whole exome-seq (WES), RNA-seq, miRNA-seq, and ChIP-seq in cancer research programs and to apply the newly discovered driver genetic alterations for prevention, early diagnosis and genome-oriented precision cancer treatment. Next Generation Sequencing in Cancer Research, Volume 2: From Basepairs to Bedsides brings together the implementation of a wide range of NGS technologies, including single-cell sequencing, in the clinical setting: discovery and validation of cancer biomarkers; standardization of NGS data production; NGS data reporting systems for clinicians; novel anti-cancer therapies  development from NGS data; conducting of clinical trials of newly investigated cancer drugs. It provides compelling evidence to signal a new future for health care and a new standard for cancer care. 606 $aCancer$xResearch 606 $aHuman genetics 606 $aBioinformatics 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aBioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15001 615 0$aCancer$xResearch. 615 0$aHuman genetics. 615 0$aBioinformatics. 615 14$aCancer Research. 615 24$aHuman Genetics. 615 24$aBioinformatics. 676 $a570285 676 $a599935 676 $a610 676 $a611.01816 676 $a614.5999 702 $aWu$b Wei$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aChoudhry$b Hani$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298296903321 996 $aNext Generation Sequencing in Cancer Research, Volume 2$92539437 997 $aUNINA