LEADER 04556nam 22007935 450 001 9910298295003321 005 20200706053056.0 010 $a3-662-46450-0 024 7 $a10.1007/978-3-662-46450-2 035 $a(CKB)3710000000394670 035 $a(EBL)2096870 035 $a(SSID)ssj0001500666 035 $a(PQKBManifestationID)11866011 035 $a(PQKBTitleCode)TC0001500666 035 $a(PQKBWorkID)11521618 035 $a(PQKB)11137994 035 $a(DE-He213)978-3-662-46450-2 035 $a(MiAaPQ)EBC2096870 035 $a(MiAaPQ)EBC3109293 035 $a(Au-PeEL)EBL3109293 035 $a(OCoLC)927513969 035 $a(PPN)185490085 035 $a(EXLCZ)993710000000394670 100 $a20150406d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPain Control /$fedited by Hans-Georg Schaible 205 $a1st ed. 2015. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2015. 215 $a1 online resource (313 p.) 225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v227 300 $aDescription based upon print version of record. 311 $a3-662-46449-7 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aEmerging concepts of pain therapy based on neuronal mechanisms -- The pharmacology of nociceptor priming -- Sodium channels and pain -- Role of nerve growth factor in pain -- Central sensitization in humans ? assessment and pharmacology -- The role of NO in the spinal cord -- The role of the endocannabinoid system in pain -- The role of glia in the spinal cord in neuropathic and inflammatory pain -- Plasticity of inhibition in the spinal cord -- Gene regulation in nociception. Modulation of peripheral inflammation by the spinal cord -- The relationship between opioids and cytokines in the spinal cord -- The role of proteases in pain. Pain-related pharmacology in the amygdala -- Pain and itch ? differences and commonalities. 330 $aThis volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the peripheral nociceptive system address the concept of hyperalgesic priming, the role of voltage-gated sodium channels in different inflammatory and neuropathic pain states, the hyperalgesic effects of NGF in different tissues and in inflammatory and neuropathic pain states, and the contribution of proteinase activated receptors (PAR) to the development of pain in several chronic pain conditions. Chapters on nociceptive mechanisms in the spinal cord address the particular role of NO and of glial cell activation in the generation and maintenance of inflammatory and neuropathic pain and it discusses the potential role of local inhibitory interneurons, of the endogenous endocannabinoid system and the importance of non-neuronal immune mechanisms in opioid signaling in the control of pain. Furthermore, it is presented how spinal mechanisms contribute to the expression of peripheral inflammation. 410 0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v227 606 $aPharmacology 606 $aPain medicine 606 $aMedical biochemistry 606 $aHuman physiology 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aPain Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H47003 606 $aMedical Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/H35005 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 615 0$aPharmacology. 615 0$aPain medicine. 615 0$aMedical biochemistry. 615 0$aHuman physiology. 615 14$aPharmacology/Toxicology. 615 24$aPain Medicine. 615 24$aMedical Biochemistry. 615 24$aHuman Physiology. 676 $a610 676 $a612 676 $a612015 676 $a615 676 $a616.0472 702 $aSchaible$b Hans-Georg$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298295003321 996 $aPain control$91076535 997 $aUNINA