LEADER 06258nam 22007215 450 001 9910298293003321 005 20231107181804.0 010 $a1-4939-2480-X 024 7 $a10.1007/978-1-4939-2480-6 035 $a(CKB)3710000000412040 035 $a(EBL)3565665 035 $a(SSID)ssj0001500625 035 $a(PQKBManifestationID)11810731 035 $a(PQKBTitleCode)TC0001500625 035 $a(PQKBWorkID)11517794 035 $a(PQKB)11766253 035 $a(DE-He213)978-1-4939-2480-6 035 $a(MiAaPQ)EBC3565665 035 $a(PPN)186030231 035 $a(EXLCZ)993710000000412040 100 $a20150508d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCell Signaling During Mammalian Early Embryo Development /$fedited by Henry J. Leese, Daniel R. Brison 205 $a1st ed. 2015. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2015. 215 $a1 online resource (224 p.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v843 300 $aDescription based upon print version of record. 311 $a1-4939-2479-6 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPreface; Contents; Contributors; Chapter-1; Cell Signalling During Blastocyst Morphogenesis; 1.1 Introduction; 1.2 Intrinsic Signals Regulating Blastocyst Morphogenesis; 1.2.1 Cell Signalling at Fertilisation and Activation of the Development Programme; 1.2.2 Cell Signalling at Compaction; 1.2.3 Cell Signalling and Blastocyst Formation; 1.2.4 Cell Signalling and the Stabilisation of Emergent Cell Lineages; 1.3 Extrinsic Signalling Pathways; 1.3.1 Insulin and Amino Acid Signalling-The mTORC Signalling Network; 1.3.2 Energy Homeostasis-The AMPK Signalling Network 327 $a2.8 Expression of Components of the MTOR Cell Signaling Pathway in Ovine Conceptus Trophectoderm2.9 Amino Acids Stimulate MTOR Cell Signaling; 2.10 Beneficial Effects of Dietary Arginine Supplementation on Embryonic/Fetal Survival and Growth in Mammals; 2.11 Summary; References; Chapter-3; The Role of Hexosamine Biosynthesis and Signaling in Early Development; 3.1 The Embryo and its Environment; 3.2 A Role for Glucose in Early Development?; 3.3 Glucose Primes Embryos to Adapt to Their Environment; 3.4 Hexosamine Biosynthesis: An Embryonic Nutrient-Sensing Pathway 327 $a3.5 The Response Path: N-Linked Vs. O-Linked Glycosylation?3.6 Hexosamine Signalling: A Nutrient Response Pathway; 3.6.1 The Enzymes; 3.6.2 The Targets; 3.7 O-GlcNAcylation in Development; 3.8 The HSP: Sensor of an Adverse Environment?; 3.9 Perturbed O-GlcNAcylation and Embryo Development; 3.9.1 Embryotoxic Effects of Hyperglycemia and O-GlcNAcylation; 3.9.2 Glucosamine as a Hyperglycemic Mimetic; 3.9.3 Periconceptional HSP Pertubation and Postnatal Outcomes; 3.10 Nutrient Stress, Embryonic Programming and O-Linked Glycosylation; 3.11 What Makes the Early Embryo More Susceptible? 327 $a3.12 ConclusionReferences; Chapter-4; Molecular Biology of the Stress Response in the Early Embryo and its Stem Cells; 4.1 Introduction; 4.2 Early events in Embryogenesis Balancing Anabolism and Stress During Early Embryonic Programming; 4.2.1 Defining Stress and Categorizing Classes of Stress by the Transcription Factors in the Survival Responses of Somatic Cells, Stem Cells and Embryos; 4.2.2 Integrating Maternal Nutritional/energy Status to Enable Peri-Implantation Embryogenesis to use Energy for Normal or Stressed Development; 4.2.3 Stress During IVF/ART 327 $a4.2.4 Using Stress Responses to Optimize IVF 330 $aThe book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v843 606 $aEmbryology 606 $aCell biology 606 $aReproductive medicine 606 $aEmbryology$3https://scigraph.springernature.com/ontologies/product-market-codes/L18010 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aReproductive Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H56002 615 0$aEmbryology. 615 0$aCell biology. 615 0$aReproductive medicine. 615 14$aEmbryology. 615 24$aCell Biology. 615 24$aReproductive Medicine. 676 $a573.619 702 $aLeese$b Henry J$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBrison$b Daniel R$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298293003321 996 $aCell Signaling During Mammalian Early Embryo Development$92502135 997 $aUNINA