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100   $a20150420d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aStem Cell Biology in Neoplasms of the Central Nervous System /$fedited by Moneeb Ehtesham
205   $a1st ed. 2015.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015.
215   $a1 online resource (200 p.)
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v853
300   $aDescription based upon print version of record.
311   $a3-319-16536-4 
320   $aIncludes bibliographical references and index.
327   $aRegulation of Subventricular Zone-Derived Cells Migration in the Adult Brain -- The SVC and Its Relationship to Stem Cell Based Neuro-oncogenesis. - Isolation and characterization of stem cells for human central nervous system malignancies. - The role of stem cells in pediatric central nervous system malignancies. - Laboratory models for central nervous system tumor stem cell research. - Radiation Therapy for Glioma Stem Cells -- Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma -- Immunobiology and Immunotherapeutic targeting of glioma stem cells -- Emerging strategies for the treatment of tumor stem cells in central nervous system malignancies.
330   $aThis volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used.   The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v853
606   $aCancer$xResearch
606   $aStem cells
606   $aNeurosciences
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aStem Cells$3https://scigraph.springernature.com/ontologies/product-market-codes/L16010
606   $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006
615  0$aCancer$xResearch.
615  0$aStem cells.
615  0$aNeurosciences.
615 14$aCancer Research.
615 24$aStem Cells.
615 24$aNeurosciences.
676   $a571.6
676   $a610
676   $a612.8
676   $a614.5999
702   $aEhtesham$b Moneeb$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298292303321
996   $aStem Cell Biology in Neoplasms of the Central Nervous System$92521366
997   $aUNINA