LEADER 04266nam 22007815 450 001 9910298290103321 005 20200701103918.0 010 $a94-017-9245-3 024 7 $a10.1007/978-94-017-9245-5 035 $a(CKB)3710000000281392 035 $a(EBL)1967987 035 $a(OCoLC)895161928 035 $a(SSID)ssj0001385798 035 $a(PQKBManifestationID)11781007 035 $a(PQKBTitleCode)TC0001385798 035 $a(PQKBWorkID)11349154 035 $a(PQKB)11361776 035 $a(DE-He213)978-94-017-9245-5 035 $a(MiAaPQ)EBC1967987 035 $a(PPN)183095766 035 $a(EXLCZ)993710000000281392 100 $a20141111d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAdvance in Structural Bioinformatics /$fedited by Dongqing Wei, Qin Xu, Tangzhen Zhao, Hao Dai 205 $a1st ed. 2015. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2015. 215 $a1 online resource (380 p.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v827 300 $aDescription based upon print version of record. 311 $a94-017-9244-5 320 $aIncludes bibliographical references. 327 $aIntroduction to Structural Bioinformatics -- Modeling and Structure Determination -- The Structure Prediction of Biological Macromolecules -- The Biological Macromolecules in Computational Biology -- The Functional Analysis of Biological Macromolecules -- The Structure-Based Drug Design. 330 $aThis text examines in detail mathematical and physical modeling, computational methods and systems for obtaining and analyzing biological structures, using pioneering research cases as examples. As such, it emphasizes programming and problem-solving skills. It provides information on structure bioinformatics at various levels, with individual chapters covering introductory to advanced aspects, from fundamental methods and guidelines on acquiring and analyzing genomics and proteomics sequences, the structures of protein, DNA and RNA, to the basics of physical simulations and methods for conformation searches. This book will be of immense value to researchers and students in the fields of bioinformatics, computational biology and chemistry. Dr. Dongqing Wei is a Professor at the Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. His research interest is in the general area of structural bioinformatics. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v827 606 $aBioinformatics 606 $aMolecular biology 606 $aEnzymology 606 $aChemistry, Physical and theoretical 606 $aBioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15001 606 $aComputational Biology/Bioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/I23050 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aEnzymology$3https://scigraph.springernature.com/ontologies/product-market-codes/L14070 606 $aTheoretical and Computational Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C25007 615 0$aBioinformatics. 615 0$aMolecular biology. 615 0$aEnzymology. 615 0$aChemistry, Physical and theoretical. 615 14$aBioinformatics. 615 24$aComputational Biology/Bioinformatics. 615 24$aMolecular Medicine. 615 24$aEnzymology. 615 24$aTheoretical and Computational Chemistry. 676 $a572 702 $aWei$b Dongqing$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aXu$b Qin$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aZhao$b Tangzhen$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDai$b Hao$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298290103321 996 $aAdvance in Structural Bioinformatics$92499290 997 $aUNINA