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024 7 $a10.1007/978-3-662-44287-6
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035   $a(DE-He213)978-3-662-44287-6
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100   $a20141129d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aGenetics of the Mouse /$fby Jean Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
205   $a1st ed. 2015.
210  1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2015.
215   $a1 online resource (417 p.)
300   $aDescription based upon print version of record.
311   $a3-662-44286-8 
320   $aIncludes bibliographical references.
327   $aOrigins of the Laboratory Mouse -- Basic Concepts of Reproductive Biology And Genetics -- Cytogenetics -- Gene Mapping -- The Mouse Genome -- Epigenetic Control of Genome Expression -- Mutations and Experimental Mutagenesis -- Transgenesis and Transgenic Animals -- The Different Categories of Genetically Standardized Populations of Laboratory Mice -- Quantitative Traits and Quantitative Genetics.
330   $aThis book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits.   The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided.   In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.
606   $aAnimal genetics
606   $aAnimal models in research
606   $aTransgenic organisms
606   $aGene expression
606   $aGenetic engineering
606   $aAnimal Genetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32030
606   $aAnimal Models$3https://scigraph.springernature.com/ontologies/product-market-codes/L25050
606   $aTransgenics$3https://scigraph.springernature.com/ontologies/product-market-codes/L25025
606   $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010
606   $aGenetic Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/C12037
615  0$aAnimal genetics.
615  0$aAnimal models in research.
615  0$aTransgenic organisms.
615  0$aGene expression.
615  0$aGenetic engineering.
615 14$aAnimal Genetics and Genomics.
615 24$aAnimal Models.
615 24$aTransgenics.
615 24$aGene Expression.
615 24$aGenetic Engineering.
676   $a570
676   $a591.35
676   $a611.01816
676   $a616.027
676   $a660.65
700   $aGuénet$b Jean Louis$4aut$4http://id.loc.gov/vocabulary/relators/aut$01058334
702   $aBenavides$b Fernando$4aut$4http://id.loc.gov/vocabulary/relators/aut
702   $aPanthier$b Jean-Jacques$4aut$4http://id.loc.gov/vocabulary/relators/aut
702   $aMontagutelli$b Xavier$4aut$4http://id.loc.gov/vocabulary/relators/aut
906   $aBOOK
912   $a9910298288303321
996   $aGenetics of the Mouse$92499289
997   $aUNINA