LEADER 05521nam 22006615 450 001 9910298287403321 005 20200704032158.0 010 $a3-319-14544-4 024 7 $a10.1007/978-3-319-14544-0 035 $a(CKB)3710000000372009 035 $a(EBL)1997869 035 $a(OCoLC)904397965 035 $a(SSID)ssj0001465038 035 $a(PQKBManifestationID)11873778 035 $a(PQKBTitleCode)TC0001465038 035 $a(PQKBWorkID)11471024 035 $a(PQKB)10844598 035 $a(DE-He213)978-3-319-14544-0 035 $a(MiAaPQ)EBC1997869 035 $a(PPN)184896169 035 $a(EXLCZ)993710000000372009 100 $a20150303d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aProtein Kinase CK2 Cellular Function in Normal and Disease States /$fedited by Khalil Ahmed, Olaf-Georg Issinger, Ryszard Szyszka 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (386 p.) 225 1 $aAdvances in Biochemistry in Health and Disease ;$v12 300 $aDescription based upon print version of record. 311 $a3-319-14543-6 320 $aIncludes bibliographical references and index. 327 $a1. CK2 Suppression of Apoptosis -- 2. Structural Determinants of CK2 Regulation -- 3. Targeting Protein Kinase: CK2 Suppresses Pro-Survival Signaling Pathways and Growth of Gliobastoma -- 4. The Roles of CK2 in Drosophila Neurogenesis -- 5. Targeting the CK2 Subunit Interface: Challenge and Usefulness -- 6. CK2 in Wnt/?-catenin signaling and embryo development -- 7. Defective expression of CK2? promotes EMT and stemness properties both required for breast cancer progression -- 8. Chemical Biology Approaches to Identify CK2 Substrates and Perform Unbiased Evaluation of CK2 Inhibitors -- 9. Development of Screening Systems and Identification of Novel Potent Inhibitors of Human Protein Kinase CK2 -- 10. Protein Kinase CK2: At the Crossroad of Regulatory Cellular Pathways -- 11. Functional Regulation of DYRK Family Protein Kinases by Cellular Binding Partners -- 12. Regulation of CK2 in pancreatic ? cells -- 13. Recent impressions from the configurational and conformational space captured by protein kinase CK2 -- 14. Role of CK2 in Plant Responses to Abiotic Stress -- 15. ?Genuine? Casein Kinase: The False Sister of CK2: Phosphorylates-Secreted Proteins -- 16. CK2: ? A Novel Player in L-DOPA induced dyskinesia in a mouse model of Parkinson?s disease -- 17. CK2 function in the regulation of Akt Pathway: new findings and perspectives -- 18. CK2 structure from yeast to human -- 19. Cellular zinc signaling is triggered by CK2 -- 20. A Nanomedicine Approach to Targeting CK2 for Cancer therapy -- 21. Bisubstrate approach for construction of high-affinity inhibitors and optical probes for protein kinase CK2. 330 $aThe field of protein kinases has greatly impacted our understanding of the basic mechanisms in cell function. The field has also been a major focus of drug development that considers the broad reach of the protein kinase function under diverse conditions. One member of the kinome, protein kinase CK2, continues to emerge as a major signaling molecule involved in diverse functions in health and disease. This kinase has unique features, most notably its ubiquitous and highly conserved nature. Its vast number of potential substrates exemplifies its involvement in various functions in cells under both the normal and diseased states. Of particular note is the observation that due to its ubiquitous nature, CK2 has been found to be dysregulated in all cancers that have been examined. As such, it is now being considered a potentially important target for cancer therapy. Protein Kinase CK2 plays equally important functions in development and intracellular activities, and has a global impact on cell growth and proliferation. An additional key function of CK2 is the impact of its activity on cell death processes. Given the vast nature of its functions, CK2 has been proposed to serve as a ?master regulator? of cell function. The chapters included in this work cover a wide range of topics dealing with some of the functions mentioned above, providing an important starting point for research investigators and graduate students interested in this field. 410 0$aAdvances in Biochemistry in Health and Disease ;$v12 606 $aCancer research 606 $aProteins  606 $aApoptosis 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aApoptosis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16060 615 0$aCancer research. 615 0$aProteins . 615 0$aApoptosis. 615 14$aCancer Research. 615 24$aProtein Science. 615 24$aApoptosis. 676 $a612/.015756 702 $aAhmed$b Khalil$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aIssinger$b Olaf-Georg$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSzyszka$b Ryszard$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298287403321 996 $aProtein Kinase CK2 Cellular Function in Normal and Disease States$92502129 997 $aUNINA