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010   $a1-4939-2053-7
024 7 $a10.1007/978-1-4939-2053-2
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035   $a(DE-He213)978-1-4939-2053-2
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100   $a20141126d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aReceptor Tyrosine Kinases: Structure, Functions and Role in Human Disease /$fedited by Deric L. Wheeler, Yosef Yarden
205   $a1st ed. 2015.
210  1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2015.
215   $a1 online resource (452 p.)
300   $aDescription based upon print version of record.
311   $a1-4939-2052-9 
320   $aIncludes bibliographical references and index.
327   $aThe Eukaryotic Protein Kinase Superfamily -- Evolution of Receptor Tyrosine Kinases -- RTKs in Invertebrates: Lessons in Signal Transduction -- Cell Signaling by Receptor Tyrosine Kinases -- Nuclear Signaling of Receptor Tyrosine Kinases -- Computational and Modeling Aspects of RTK Networks -- Endocytosis of Receptor Tyrosine Kinases -- Structural Features of the Ligand-Binding Extracellular Domain -- Structural Features of the Kinase Domain -- Targeting RTKs in Cancer.-  Mouse Models of Receptor Tyrosine Kinases.
330   $aReceptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in humans, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to The Receptor Tyrosine Kinase Family, which refers to specific subfamilies of RTKs, along with their unique landmarks.
606   $aCell biology
606   $aProteins 
606   $aCancer research
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
606   $aReceptors$3https://scigraph.springernature.com/ontologies/product-market-codes/L14110
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
615  0$aCell biology.
615  0$aProteins .
615  0$aCancer research.
615 14$aCell Biology.
615 24$aReceptors.
615 24$aCancer Research.
676   $a570
676   $a571.6
676   $a572696
676   $a614.5999
702   $aWheeler$b Deric L$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aYarden$b Yosef$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298286703321
996   $aReceptor Tyrosine Kinases: Structure, Functions and Role in Human Disease$92508852
997   $aUNINA