LEADER 00937nam0-22003011i-450- 001 990006343750403321 005 20110307105437.0 035 $a000634375 035 $aFED01000634375 035 $a(Aleph)000634375FED01 035 $a000634375 100 $a20000112g18331836km-y0itay50------ba 101 0 $afre 102 $aFR 105 $ay-------001yy 200 1 $aHistoire générale depuis les temps les plus reculés jusqu'a l'an 1832$fCharles de Rotteck$gtraduit de l'allemand par Simon Gunjer 210 $aParis$cChez Firmin Didot Fréres$d1833-1836 215 $a4 v.$d24 cm 676 $a940.2 700 1$aDe Rotteck,$bCharles$0407623 702 1$aGunjer,$bSimon 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990006343750403321 952 $aXXI D 21$b10632$fFGBC 959 $aFGBC 996 $aHistoire générale depuis les temps les plus reculés jusqu'a l'an 1832$9656800 997 $aUNINA LEADER 03969nam 22006495 450 001 9910298283703321 005 20200910212651.0 010 $a3-319-14340-9 024 7 $a10.1007/978-3-319-14340-8 035 $a(CKB)3710000000359089 035 $a(EBL)1998345 035 $a(SSID)ssj0001451864 035 $a(PQKBManifestationID)11835729 035 $a(PQKBTitleCode)TC0001451864 035 $a(PQKBWorkID)11478902 035 $a(PQKB)11459999 035 $a(DE-He213)978-3-319-14340-8 035 $a(MiAaPQ)EBC1998345 035 $a(PPN)184494354 035 $a(EXLCZ)993710000000359089 100 $a20150217d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTextbook of Cell Signalling in Cancer $eAn Educational Approach /$fby Jacques Robert 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (341 p.) 300 $aDescription based upon print version of record. 311 $a3-319-14339-5 320 $aIncludes bibliographical references. 327 $aGrowth Factors and Tyrosine Kinase Receptors -- MAP Kinases Pathway -- Phosphatidylinositol 3-Kinase Pathway -- Cytokine Pathway -- TGF? Pathway -- G-proteins?coupled Receptors -- Wnt Pathway -- Notch Pathway -- Hedgehog Pathway -- Integrins -- Semaphorins and Adhesion Molecules -- Toll-like Receptors, Interleukin 1 (IL1) and NF?B -- Lymphocyte Receptors Pathways -- Nuclear Receptors Pathways -- Ion Channels?coupled Receptors -- Signalling by Oxygen and Nitric Oxide -- Cell Cycle Control -- Apoptosis Induction and Regulation. 330 $aThis book provides a simplified, yet comprehensive, overview of the signalling pathways operating between and inside cells, which will help younger oncologists find their way in the labyrinth of signalling pathways and in the multitude of signals and signal receptors, transducers and effectors that contribute to oncogenesis. This comprehensive reference text is based on the master?s courses delivered by Prof. Jacques Robert to graduate students at the University of Bordeaux, France. It includes a large number of colour schemas and figures that have been improved year after year for educational purposes. Signalling pathways are described individually and in depth, but without ignoring the multiplicity of interconnections and crosstalk. The presentation of each pathway is followed by a brief description of the alterations found in cancers as well as of the targeted pharmacological approaches that can be used to prevent or overcome the consequences of these oncogenic alterations. The basic mechanisms of molecular biology at the DNA replication, RNA transcription and protein activity levels are presented in a series of didactic annexes, enabling readers to better understand the alterations in signalling pathways. 606 $aOncology 606 $aMedicine 606 $aPharmacology 606 $aCytology 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 615 0$aOncology. 615 0$aMedicine. 615 0$aPharmacology. 615 0$aCytology. 615 14$aOncology. 615 24$aBiomedicine, general. 615 24$aPharmacology/Toxicology. 615 24$aCell Biology. 676 $a614.5999 700 $aRobert$b Jacques$4aut$4http://id.loc.gov/vocabulary/relators/aut$0425177 906 $aBOOK 912 $a9910298283703321 996 $aTextbook of Cell Signalling in Cancer$92537229 997 $aUNINA