LEADER 04992nam 22006735 450 001 9910298282903321 005 20200703051429.0 010 $a3-319-08945-5 024 7 $a10.1007/978-3-319-08945-4 035 $a(CKB)3710000000269472 035 $a(EBL)1965336 035 $a(SSID)ssj0001372159 035 $a(PQKBManifestationID)11785428 035 $a(PQKBTitleCode)TC0001372159 035 $a(PQKBWorkID)11301645 035 $a(PQKB)10512003 035 $a(DE-He213)978-3-319-08945-4 035 $a(MiAaPQ)EBC1965336 035 $z(PPN)25886883X 035 $a(PPN)182093425 035 $a(EXLCZ)993710000000269472 100 $a20141031d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMechanisms of Circadian Systems in Animals and Their Clinical Relevance /$fedited by Raúl Aguilar-Roblero, Mauricio Díaz-Muñoz, Mária Luisa Fanjul-Moles 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (396 p.) 300 $aDescription based upon print version of record. 311 $a3-319-08944-7 320 $aIncludes bibliographical references and index. 327 $a1. Introduction to Circadian Rhythms, Clocks and its Genes -- 2. Oxidative Stress and its Role in the Synchronization of Circadian Rhythms in Crustaceans, an Ecological Perspective -- 3. Control of Rest: Activity Behavior by the Central Clock in Drosophila -- 4. Biological Rhythmicity in Subterranean Animals, a Function Risking Extinction? -- 5. Avian Circadian Organization -- 6. Functional Organization of Circadian Timing System of Diurnal Primate (Marmoset) -- 7. Intracellular Calcium as a Clock Output from Suprachiasmatic Nuclei Neurons -- 8. GABAA Receptor-Mediated Neurotransmission in the Suprachiasmatic Nucleus -- 9. Network Properties in the SCN Function -- 10. Behavioral, Physiological and Neuroendocrine Circadian Rhythms during Lactation -- 11. A Time to Wake, a Time to Sleep -- 12. Chronostasis: The Timing of Physiological Systems -- 13. Circadian rhythm and Food/Nutrition -- 14. Physiopathology of Circadian Rhythms: Understanding the Biochemical Mechanisms of Obesity and Cancer -- 15. Effects of Circadian Disruption on Physiology and Pathology: from Bench to Clinic (and Back) -- 16. Circadian Dysfunction in Huntington?s Disease -- 17. Is it Possible to Modify Clock Genes to Improve Health?. 330 $aWell known experts in the field of Chronobiology from around the world, provide an integrative view of the state of the art of circadian biology. At present, genetic and epigenetic interaction of regulatory pathways among circadian oscillators, metabolic networks, cellular differentiation and neuronal communication are subject of intense scrutiny. The book is organized in three sections: The first includes selected examples of the circadian systems of crustaceans, insects, fish, birds and mammals. The second is a detailed view of the physiological mechanisms underlying the circadian clocks in mammals. Finally, in the third section some examples of the relevance of circadian biology and circadian misalignment to health and disease are provided including nutrition and metabolism, obesity, cancer, cardiovascular and pulmonary diseases, Huntington and affective diseases. This section concludes with a brief review on gene therapy and its potential use as a therapeutic tool to correct ?clock genes? pathologies. This book is aimed at all those interested in contemporary aspects of physiology, biochemistry and molecular biology applied to the study and characterization of timing systems.. It could be used as an initial approach to this field, but it also provides updated information for those already familiar with the fascinating field of Chronobiology. 606 $aNeurosciences 606 $aHuman physiology 606 $aNeurology  606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001 615 0$aNeurosciences. 615 0$aHuman physiology. 615 0$aNeurology . 615 14$aNeurosciences. 615 24$aHuman Physiology. 615 24$aNeurology. 676 $a610 676 $a612 676 $a612.8 676 $a616.8 702 $aAguilar-Roblero$b Raúl$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDíaz-Muñoz$b Mauricio$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aFanjul-Moles$b Mária Luisa$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298282903321 996 $aMechanisms of Circadian Systems in Animals and Their Clinical Relevance$92502125 997 $aUNINA