LEADER 04844nam 22006975 450 001 9910298281103321 005 20200630031213.0 010 $a3-319-10533-7 024 7 $a10.1007/978-3-319-10533-8 035 $a(CKB)3710000000248960 035 $a(EBL)1968672 035 $a(OCoLC)892521610 035 $a(SSID)ssj0001353627 035 $a(PQKBManifestationID)11831915 035 $a(PQKBTitleCode)TC0001353627 035 $a(PQKBWorkID)11316403 035 $a(PQKB)10239167 035 $a(DE-He213)978-3-319-10533-8 035 $a(MiAaPQ)EBC1968672 035 $z(PPN)258860758 035 $a(PPN)18134937X 035 $a(EXLCZ)993710000000248960 100 $a20140923d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDNA Replication Control in Microbial Cell Factories /$fby Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (56 p.) 225 1 $aSpringerBriefs in Microbiology,$x2191-5385 300 $aDescription based upon print version of record. 311 $a3-319-10532-9 320 $aIncludes bibliographical references. 327 $aIntroduction.- Coordinating duplication of genetic material with cell growth ? current views and old questions.- Structural organization of cellular processes and the regulation of cell cycle -- The link between metabolism and DNA replication -- Transcriptional activation ? the unsolved problem -- Activity of DnaA is inhibited by components of translation machinery -- Nucleoid-associated proteins modulate activity of the DnaA initiator -- Interaction of DnaA with acidic components of fluid cellular membrane regulates its nucleotide-bound status and binding to oriC -- Influence of DNA replication on cell structure and function -- Conclusions. 330 $aThis work describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control of  activity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition, similarities of the mechanisms of regulation of DNA replication operating in prokaryotic and eukaryotic cells are identified, and implications for understanding more complex processes, like carcinogenesis are suggested. Studies of recent years provided evidence that regulation of DNA replication in bacteria is more complex than previously anticipated. Multiple layers of control seem to ensure coordination of this process with the increase of cellular mass and the division cycle. Metabolic processes and membrane composition may serve as points where integration of genome replication with growth conditions occurs. It is also likely that coupling of  DNA synthesis with cellular metabolism may involve interactions of replication proteins with other macromolecular complexes, responsible for various cellular processes. Thus, the exact set of factors participating in triggering the replication initiation may differ depending on growth conditions. Therefore, understanding the regulation of DNA duplication requires placing this process in the context of the current knowledge on bacterial metabolism, as well as cellular and chromosomal structure. Moreover, in both Escherichia coli and eukaryotic cells, replication initiator proteins were shown to play other roles in addition to driving the assembly of replication complexes, which constitutes another, yet not sufficiently understood, layer of coordinating DNA replication with the cell cycle. 410 0$aSpringerBriefs in Microbiology,$x2191-5385 606 $aMicrobiology 606 $aCell biology 606 $aMicrobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L23004 606 $aApplied Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/C12010 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 615 0$aMicrobiology. 615 0$aCell biology. 615 14$aMicrobiology. 615 24$aApplied Microbiology. 615 24$aCell Biology. 676 $a572.8/645 676 $a579 700 $aGlinkowska$b Monika$4aut$4http://id.loc.gov/vocabulary/relators/aut$01061080 702 $aBoss$b Lidia$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aWegrzyn$b Grzegorz$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298281103321 996 $aDNA Replication Control in Microbial Cell Factories$92517345 997 $aUNINA