LEADER 05403nam 22007455 450 001 9910298280803321 005 20200630000432.0 010 $a4-431-55227-8 024 7 $a10.1007/978-4-431-55227-7 035 $a(CKB)3710000000332425 035 $a(EBL)1966209 035 $a(OCoLC)899495735 035 $a(SSID)ssj0001424623 035 $a(PQKBManifestationID)11802004 035 $a(PQKBTitleCode)TC0001424623 035 $a(PQKBWorkID)11367549 035 $a(PQKB)10811673 035 $a(DE-He213)978-4-431-55227-7 035 $a(MiAaPQ)EBC1966209 035 $a(PPN)183516931 035 $a(EXLCZ)993710000000332425 100 $a20150105d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTargeted Genome Editing Using Site-Specific Nucleases $eZFNs, TALENs, and the CRISPR/Cas9 System /$fedited by Takashi Yamamoto 205 $a1st ed. 2015. 210 1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2015. 215 $a1 online resource (206 p.) 300 $aDescription based upon print version of record. 311 $a4-431-55226-X 320 $aIncludes bibliographical references at the end of each chapters. 327 $aPreface -- Part 1 Basics of Genome Editing -- 1 Genome Editing Using Zinc-Finger Nucleases (ZFNs) and Transcription Activator-Like Effector Nucleases (TALENs) (Hiroshi Ochiai and Takashi Yamamoto)-. 2 CRISPR/Cas9: The Leading Edge of Genome Editing Technology (Tetsushi Sakuma and Takashi Yamamoto)-. Part 2 Genome Editing in Cultured Cells and Various Organisms -- 3 Editing in Cultured Human Cells: From Cell Lines to iPS Cells (Hongmei Lisa Li and Akitsu Hotta)-. 4 Genome Editing in Nematode (Takuma Sugi)-. 5 Highly Efficient Targeted Gene Disruption in the Silkworm, Bombyx mori, Using Genome Editing Tools (Takaaki Daimon)-. 6 Genome Editing in Sea Urchin (Naoaki Sakamoto)-. 7 Genome Editing in Ascidians (Nicholas Treen and Yasunori Sasakura)-. 8 Genome Editing in Zebrafish and Medaka (Atsuo Kawahara, Taijiro Yabe, Satoshi Ansai, Shinji Takada, and Masato Kinoshita)-. 9 Genome Editing Using Site-Specific Nucleases in Amphibians (Ken-ichi T. Suzuki and Toshinori Hayashi)-. 10 Genome Editing in Mice Using CRISPR/Cas  (Samantha AM Young, Mark Baker, and Masahito Ikawa)-. 11 Genome Editing in Mice Using TALENs (Tomomi Aida)-. 12 Engineered Nucleases Lead to Genome Editing Revolution in Rats (Kazuto Yoshimi, Takehito Kaneko, Birger Voigt, and Tomoji Mashimo)-. 13 Genome Editing in Higher Plants (Yuriko Osakabe and Keishi Osakabe). 330 $aThis book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields. 606 $aTransgenic organisms 606 $aDevelopmental biology 606 $aCell biology 606 $aAnimal genetics 606 $aPlant genetics 606 $aTransgenics$3https://scigraph.springernature.com/ontologies/product-market-codes/L25025 606 $aDevelopmental Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L18000 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aAnimal Genetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32030 606 $aPlant Genetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32020 615 0$aTransgenic organisms. 615 0$aDevelopmental biology. 615 0$aCell biology. 615 0$aAnimal genetics. 615 0$aPlant genetics. 615 14$aTransgenics. 615 24$aDevelopmental Biology. 615 24$aCell Biology. 615 24$aAnimal Genetics and Genomics. 615 24$aPlant Genetics and Genomics. 676 $a570 676 $a571.6 676 $a571.8 676 $a581.35 702 $aYamamoto$b Takashi$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298280803321 996 $aTargeted Genome Editing Using Site-Specific Nucleases$92508846 997 $aUNINA