LEADER 05883nam 22007095 450 001 9910298280603321 005 20200701103805.0 010 $a4-431-55212-X 024 7 $a10.1007/978-4-431-55212-3 035 $a(CKB)3710000000332427 035 $a(EBL)1966201 035 $a(OCoLC)899987208 035 $a(SSID)ssj0001424565 035 $a(PQKBManifestationID)11784574 035 $a(PQKBTitleCode)TC0001424565 035 $a(PQKBWorkID)11367010 035 $a(PQKB)11425500 035 $a(DE-He213)978-4-431-55212-3 035 $a(MiAaPQ)EBC1966201 035 $a(PPN)183516869 035 $a(EXLCZ)993710000000332427 100 $a20150107d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPolyamines $eA Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism /$fedited by Tomonobu Kusano, Hideyuki Suzuki 205 $a1st ed. 2015. 210 1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2015. 215 $a1 online resource (324 p.) 300 $aDescription based upon print version of record. 311 $a4-431-55211-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPART I BIOSYNTHESIS OF POLYAMINES,- 1 Biosynthesis of Polyamines in Eukaryotes, Archaea, and Bacteria -- 2 Long-Chain and Branched Polyamines in Thermophilic Microbes -- 3 Regulation and Diversity of Polyamine Biosynthesis in Plants -- PART II CATABOLISM OF POLYAMINES -- 4 Polyamine Catabolism in Prokaryotes -- 5 Mammalian Polyamine Catabolism -- 6 Polyamine Catabolism in Plants -- PART III POLYAMINE HOMEOSTASIS -- 7 Antizyme -- 8 Bacterial Antizyme -- 9 Polyamine Homeostasis in Plants: The Role(s) of Evolutionarily Conserved Upstream ORFs -- PART IV ROLES OF POLYAMINES IN GROWTH -- 10 Role of the Polyamine Spermidine as a Precursor for Hypusine Modification in eIF5A -- 11 The Polyamine Modulon: Genes Encoding Proteins Whose Synthesis Is Enhanced by Polyamines at the Level of Translation -- 12 Protein Synthesis and Polyamines in Thermophiles: Effect of Polyamines on Nucleic Acid Maintenance and Gene Expression -- PART V ROLES OF POLYAMINES IN SURVIVAL -- 13 Polyamines in Plant Stress Response -- PART VI POLYAMINE TRANSPORTERS -- 14 Recent Advances in Bacterial Polyamine Transport Systems -- 15 Polyamine Transport Systems in Plants -- PART VII POLYAMINE-DERIVED SECONDARY METABOLITES -- 16 Polyamine-Derived Alkaloids in Plants: Molecular Elucidation of Biosynthesis -- 17 Polyamine Toxins from Spiders and Wasps -- PART VIII ACTION OF POLYAMINES ON ION CHANNELS -- 18 Polyamine Block of Inwardly Rectifying Potassium (Kir) Channels -- 19 Polyamine Action on Plant Ion Channels and Pumps -- 20 Regulation of N-Methyl-d-Aspartate Receptors by Spermine and Ifenprodil -- PART IX POLYAMINES AND LONGEVITY -- 21 Polyamines and Longevity in Mammals -- 22 Polyamine Interactions with Plant Hormones: Crosstalk at Several Levels -- PART X DIAGNOSIS AND DRUG TARGETS -- 23 N1, N12-Diacetylspermine in Human Urine: Performance as a Tumor Marker, Quantification, Production, and Excretion -- 24 Targeting the Polyamine Biosynthetic Pathway in Parasitic Protozoa. 330 $aThis book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers. 606 $aBiochemistry 606 $aCytology 606 $aHuman physiology 606 $aMolecular biology 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 615 0$aBiochemistry. 615 0$aCytology. 615 0$aHuman physiology. 615 0$aMolecular biology. 615 14$aBiochemistry, general. 615 24$aCell Biology. 615 24$aHuman Physiology. 615 24$aMolecular Medicine. 676 $a570 676 $a571.6 676 $a572 676 $a611.01816 702 $aKusano$b Tomonobu$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSuzuki$b Hideyuki$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298280603321 996 $aPolyamines$981985 997 $aUNINA