LEADER 05304nam 22006975 450 001 9910298280403321 005 20200701121802.0 010 $a4-431-55166-2 024 7 $a10.1007/978-4-431-55166-9 035 $a(CKB)3710000000342643 035 $a(EBL)1966187 035 $a(SSID)ssj0001424568 035 $a(PQKBManifestationID)11891914 035 $a(PQKBTitleCode)TC0001424568 035 $a(PQKBWorkID)11363963 035 $a(PQKB)11484200 035 $a(DE-He213)978-4-431-55166-9 035 $a(MiAaPQ)EBC1966187 035 $a(PPN)183516702 035 $a(EXLCZ)993710000000342643 100 $a20150123d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPresynaptic Terminals /$fedited by Sumiko Mochida 205 $a1st ed. 2015. 210 1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2015. 215 $a1 online resource (368 p.) 300 $aDescription based upon print version of record. 311 $a4-431-55165-4 320 $aIncludes bibliographical references and index. 327 $aPreface -- Part 1 Overview -- 1 Overview: Presynaptic Terminal Proteins Orchestrate Stepwise Synaptic Vesicle Phases (Sumiko Mochida) -- Part 2 Presynaptic Active Zone Proteins -- 2 Active Zone Assembly (Thomas Dresbach) -- 3 Network of Protein-Protein Interaction at the Presynaptic Active Zone (Toshihisa Ohtsuka) -- Part 3 Synaptic Vesicle Fusion.- 4 Fusion Machinery: SNARE Protein Complex (Ira Milosevic and Jakob B. Sørensen).- 5 Roles of Tomosyn in Neurotransmitter Release (Yasunori Yamamoto and Toshiaki Sakisaka).- 6 Regulation of SNAREs: Complexin (Hiroshi Tokumaru).- 7 The Synaptic Vesicle V-ATPase: A Regulatory Link Between Loading and Fusion? (Oussama El Far and Michael Seager).- 8 Ca2+ Sensors: Synaptotagmins (Tei-ichi Nishiki, Kentaro Kuroki, Toshio Masumoto, and Hideki Matsui).- 9 Regulation of Active Zone Ca2+ Channels (Karina Leal and Sumiko Mochida) -- Part 4 Synaptic Vesicle Endocytosis -- 10 Endocytic Machinery at the Neuronal Synapse (Ira Milosevic) -- 11 Dynamin is a Key Molecule to Decode Action Potential Firing (Shota Tanifuji and Sumiko Mochida) -- Part 5 Synaptic Vesicle Refilling and Storage -- 12 Transport of Amino Acid Neurotransmitters Into Synaptic Vesicles (Shigeo Takamori) -- 13 Synapsins and Synaptic Vesicle Storage (Fabrizia C. Guarnieri, Fabio Benfenati, and Flavia Valtorta) -- Part 6 Synaptic Vesicle Pools -- 14 Synaptic Vesicle Pools: Classical and Emerging Roles (Sven Truckenbrodt and Silvio O. Rizzoli) -- BM Index. 330 $aThis book brings together leading international experts to discuss recent advances in functional studies on key proteins and protein complexes involved in each synaptic vesicle phase. These include proteins that control the final step of neurotransmitter release, in response to a neural signal, and the first step of vesicle endocytosis, which helps maintain stable neurotransmitter release in response to unceasing neural signals arriving at presynaptic terminals. Neural networks transmit input and output signals of action potentials using chemical synapses. The strength of the signal from one to another neuron can be tuned by the neural signal itself as it induces Ca2+ entry and by other neurons? signals that modify Ca2+ entry through voltage-gated Ca2+ channels at the active zone, where chemical neurotransmitters are released from synaptic vesicles via exocytosis. Synaptic vesicles are docked and primed at the active zone prior to exocytosis and are endocytosed after exocytosis for reuse at a small presynaptic terminal. Recycled vesicles are refilled with transmitters and stored for a future round of exocytosis. Thus, synaptic vesicles in presynaptic terminals go through various phases. Each vesicle phase is well orchestrated by numerous proteins and advance step-by-step with neural activities. The fine regulations of synaptic vesicle phases by numerous proteins is an exciting subject, and systematic, well-organized explanations in this book will help the reader easily learn about complicated molecular mechanisms in presynaptic terminals. 606 $aNeurochemistry 606 $aHuman physiology 606 $aBiochemistry 606 $aNeurosciences 606 $aNeurochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/B18010 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 615 0$aNeurochemistry. 615 0$aHuman physiology. 615 0$aBiochemistry. 615 0$aNeurosciences. 615 14$aNeurochemistry. 615 24$aHuman Physiology. 615 24$aBiochemistry, general. 615 24$aNeurosciences. 676 $a572 676 $a610 676 $a612 676 $a612.8 676 $a612.8042 702 $aMochida$b Sumiko$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298280403321 996 $aPresynaptic Terminals$92517343 997 $aUNINA