LEADER 04798nam 22006615 450 001 9910298279703321 005 20231218171636.0 010 $a4-431-55381-9 024 7 $a10.1007/978-4-431-55381-6 035 $a(CKB)3710000000355448 035 $a(EBL)1963394 035 $a(SSID)ssj0001451862 035 $a(PQKBManifestationID)11836213 035 $a(PQKBTitleCode)TC0001451862 035 $a(PQKBWorkID)11479543 035 $a(PQKB)10450963 035 $a(DE-He213)978-4-431-55381-6 035 $a(MiAaPQ)EBC1963394 035 $a(PPN)184494192 035 $a(EXLCZ)993710000000355448 100 $a20150202d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSugar Chains $eDecoding the Functions of Glycans /$fedited by Tadashi Suzuki, Kazuaki Ohtsubo, Naoyuki Taniguchi 205 $a1st ed. 2015. 210 1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2015. 215 $a1 online resource (295 p.) 300 $aDescription based upon print version of record. 311 $a4-431-55380-0 320 $aIncludes bibliographical references and index. 327 $a1 N-Glycans and Quality Control of Proteins -- 2 Glycan-Mediated Protein Transport from the Endoplasmic Reticulum -- 3 Gangliosides and T-Cell Immunity -- 4 Gangliosides Regulate Tumor Properties: With Focus on the Suppression of Metastasis-Associated ppGalNAc-T13 with GM1 -- 5 Role of Glycans in Viral Infection -- 6 Discovery and Applications of a Novel Human Pluripotent Stem Cell-Specific Lectin Probe rBC2LCN -- 7 Glycan Structure and Neural Plasticity -- 8 The Involvement of Midkine, a Heparin-Binding Growth Factor, in Cancer Development -- 9 Tumor-Associated Glycans and Their Functional Roles in the Multistep Process of Human Cancer Progression -- 10 Mammalian Sialidase and Tumor Development -- 11 Roles of Glycans in Immune Evasion from NK Immunity -- 12 Glycomic Analysis of Cancer -- 13 Glyco-Predisposing Factor of Diabetes -- 14 Macrophages Govern Ganglioside GM3 Expression in Adipocytes to Regulate Adipogenesis and Insulin Signaling in Homeostatic and Pathogenic Conditions -- 15 O-Mannosyl Glycan and Muscular Dystrophy -- 16 Glycans and Chronic Obstructive Pulmonary Disease (COPD) -- 17 ?1,6-Fucosyltransferase Knockout Mice and Schizophrenia-Like Phenotype.  . 330 $aThis book presents the latest breakthrough results in glycobiology regarding the roles of glycans in relation to quality control and transport of protein, the immune system, viral infection, stem cells, the neural system, and various diseases such as cancer, diabetes, chronic obstructive pulmonary disease, muscular dystrophy, and schizophrenia. Although glycoscience has long been regarded as a very specialized field with no simple analytical method, the recent explosive progress in research continues to provide limitless evidence that glycan chains are the key component in various biological phenomena. Cell surface glycans, for example, change with developmental stages or environmental conditions and thus represent a ?face? of the cell that is utilized for identification of iPS and ES cells and as biomarkers in diagnosis or detection of cancer. This book comprises 17 chapters, each of which poses outstanding ?glyco-related? questions enabling non-specialists to have a clearer idea about what the future direction for further investigation of glycans in their own research fields will be. Also including basic information to understand the nature of glycans, this title serves as an excellent ?textbook? for researchers in diverse research fields who are not familiar with, but nevertheless interested in, glycan chains or sugar chains. 606 $aBiochemistry 606 $aCancer research 606 $aImmunology 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 615 0$aBiochemistry. 615 0$aCancer research. 615 0$aImmunology. 615 14$aBiochemistry, general. 615 24$aCancer Research. 615 24$aImmunology. 676 $a570 676 $a572 676 $a614.5999 676 $a616079 702 $aSuzuki$b Tadashi$cD.Sci.$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aOhtsubo$b Kazuaki$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aTaniguchi$b Naoyuki$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298279703321 996 $aSugar Chains$92533177 997 $aUNINA