LEADER 04572nam 22006375 450 001 9910298279403321 005 20200703231625.0 010 $a3-319-15063-4 024 7 $a10.1007/978-3-319-15063-5 035 $a(CKB)3710000000414307 035 $a(EBL)2094333 035 $a(SSID)ssj0001500626 035 $a(PQKBManifestationID)11810732 035 $a(PQKBTitleCode)TC0001500626 035 $a(PQKBWorkID)11521062 035 $a(PQKB)10903939 035 $a(DE-He213)978-3-319-15063-5 035 $a(MiAaPQ)EBC2094333 035 $a(PPN)186025653 035 $a(EXLCZ)993710000000414307 100 $a20150515d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCell Therapy for Brain Injury /$fedited by David C. Hess 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (371 p.) 300 $aDescription based upon print version of record. 311 $a3-319-15062-6 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction to Cell Therapy in Brain Injury -- Cell Based Therapeutics in Stroke: An Industry Perspective -- Autologous Mesenchymal Stem Cell Therapy in Patients with Stroke -- Treatment of Autologous Bone Marrow Mononuclear Cells for Acute and Subacute Stroke: Cell-Therapy for Acute/Subacute Stroke -- Clinical Development of MultiStemŽ for Treatment of Injuries and Diseases of the Central Nervous System -- Intra-Arterial Approaches to Stem Cell Therapy for Ischemic Stroke -- Neural Stem Cells in Stroke: Intracerebral Approaches -- The CTX Human Neural Stem Cell Line and the PISCES Stroke Trial -- Induced Pluripotent Stem Cells as a Cell-based Therapeutic in Stroke -- Induced Pluripotent Stem Cell Derived Neural Cell Types In Treatment of Stroke -- Preconditioning and Cell-based Therapeutics -- Tracking of Administered Progenitor Cells in Brain Injury and Stroke by Magnetic Resonance Imaging -- Biomaterials Application in Stem Cell Therapies for Stroke -- A Stem Cell Derived Cell-Free Therapy for Stroke: Moving Conditioned Medium into Clinical Trial -- Pathophysiology of Traumatic Brain Injury: Rationale and Role for Cellular Therapies -- Stem Cell Therapy for Neonatal Hypoxic-Ischemic Brain Injury -- Cell-Based Therapies in Neonatal Stroke -- Issues in Clinical Trial Design in Stem Cell Trials after Stroke. 330 $aThis is a review of state-of-the-art cell therapy in the treatment of stroke, traumatic brain injuries and neonatal stroke and hypoxia-ischemia using a variety of cells ranging from bone marrow derived stem cells and mesenchymal stem cells to induced pluripotent stem cells derived neural progenitors.  This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke, approaches using conditioned medium, and the "big pharma" perspective of cell therapy. Each of eighteen chapters has been contributed by a well-known leader in each field, thus providing a wealth of international perspective and expertise. Cell Therapy for Brain Injury?s breadth makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields. 606 $aStem cells 606 $aNeurosciences 606 $aNervous system$xSurgery 606 $aStem Cells$3https://scigraph.springernature.com/ontologies/product-market-codes/L16010 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aNeurosurgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H39000 615 0$aStem cells. 615 0$aNeurosciences. 615 0$aNervous system$xSurgery. 615 14$aStem Cells. 615 24$aNeurosciences. 615 24$aNeurosurgery. 676 $a570 676 $a571.6 676 $a612.8 676 $a617.48 702 $aHess$b David C$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298279403321 996 $aCell Therapy for Brain Injury$92541197 997 $aUNINA