LEADER 04967nam 22007455 450 001 9910298278403321 005 20200703091439.0 010 $a3-662-46344-X 010 $a3-662-46343-1 024 7 $a10.1007/978-3-662-46344-4 035 $a(CKB)2670000000618830 035 $a(EBL)2120590 035 $a(OCoLC)916951084 035 $a(SSID)ssj0001500620 035 $a(PQKBManifestationID)11810728 035 $a(PQKBTitleCode)TC0001500620 035 $a(PQKBWorkID)11520239 035 $a(PQKB)11074506 035 $a(DE-He213)978-3-662-46344-4 035 $a(MiAaPQ)EBC2120590 035 $a(PPN)186031351 035 $a(EXLCZ)992670000000618830 100 $a20150523d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBehavioral Neurobiology of Huntington's Disease and Parkinson's Disease /$fedited by Hoa Huu Phuc Nguyen, M. Angela Cenci 205 $a1st ed. 2015. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2015. 215 $a1 online resource (402 p.) 225 1 $aCurrent Topics in Behavioral Neurosciences,$x1866-3370 ;$v22 300 $aDescription based upon print version of record. 311 08$aPrinted edition: 9783662463437 320 $aIncludes bibliographical references and index at the end of each chapters. 327 $aClinical Aspects of Huntington?s Disease -- The Neuropathology of Huntington?s Disease -- Neurobiology of Huntington?s Disease -- Mouse Models of Huntington?s Disease -- Transgenic Rat Models of Huntington?s Disease -- Large Animal Models of Huntington?s Disease -- Therapeutic Strategies for Huntington?s Disease -- Clinical and Pathological Features of Parkinson?s Disease -- Symptomatic Models of Parkinson?s Disease and L-DOPA-Induced Dyskinesia in Non-human Primates -- Neuroinflammation in Parkinson?s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration? -- Viral Vector-Based Models of Parkinson?s Disease -- Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits -- Modeling LRRK2 Pathobiology in Parkinson?s Disease: From Yeast to Rodents -- Models of Multiple System Atrophy. 330 $aMotor dysfunction and cognitive impairment are major symptoms in both Huntington?s Disease (HD) and Parkinson?s Disease (PD). A breakthrough in HD research occurred in 1993, with the identification of the gene causing this devastating monogenetic illness. Since 1996, several genes were reported to cause familial forms of PD. Following these genetic discoveries, a variety of genetic disease models were generated, providing completely novel opportunities to explore the neurobiological basis of HD and PD. Genetic models allow us to study the earliest manifestations of the diseases both behaviorally and neuropathologically, and provide tools to probe molecular pathways of neurodegeneration. Additionally, neurotoxic animal models allow us to reproduce neurochemical and cellular events of great pathophysiological importance. In the PD field, neurotoxic animal models remain the preferred option to reproduce symptomatic features of the human disease that are responsive to dopaminergic pharmacotherapies. In addition, neurotoxic PD models are often used to investigate pathways of mitochondrial dysfunction, oxidative stress, and neuroinflammation. This book provides up-to-date reviews on current animal models of both HD and PD. These animal models are essential to investigate links between the pathobiology and the behavioral abnormalities associated with these disorders. 410 0$aCurrent Topics in Behavioral Neurosciences,$x1866-3370 ;$v22 606 $aNeurosciences 606 $aHuman genetics 606 $aNeurobiology 606 $aCell biology 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aNeurobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L25066 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 615 0$aNeurosciences. 615 0$aHuman genetics. 615 0$aNeurobiology. 615 0$aCell biology. 615 14$aNeurosciences. 615 24$aHuman Genetics. 615 24$aNeurobiology. 615 24$aCell Biology. 676 $a616.8 702 $aNguyen$b Hoa Huu Phuc$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCenci$b M. Angela$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298278403321 996 $aBehavioral Neurobiology of Huntington's Disease and Parkinson's Disease$92499279 997 $aUNINA