LEADER 07940nam 22008415 450 001 9910298277703321 005 20250609112105.0 010 $a3-319-13665-8 024 7 $a10.1007/978-3-319-13665-3 035 $a(CKB)3710000000355419 035 $a(EBL)1974076 035 $a(SSID)ssj0001451856 035 $a(PQKBManifestationID)11806896 035 $a(PQKBTitleCode)TC0001451856 035 $a(PQKBWorkID)11478287 035 $a(PQKB)11271657 035 $a(DE-He213)978-3-319-13665-3 035 $a(MiAaPQ)EBC1974076 035 $a(PPN)184499178 035 $a(MiAaPQ)EBC6241714 035 $a(EXLCZ)993710000000355419 100 $a20150205d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Neurobiology and Genetics of Nicotine and Tobacco /$fedited by David J.K. Balfour, Marcus R. Munafò 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (233 p.) 225 1 $aCurrent Topics in Behavioral Neurosciences,$x1866-3370 ;$v23 300 $aDescription based upon print version of record. 311 08$a3-319-13664-X 320 $aIncludes bibliographical references and index. 327 $aPreface; Contents; 1 Structure of Neuronal Nicotinic Receptors; Abstract; 1 Introduction; 2 Overall Structure of Nicotinic Subtypes; 2.1 Orthosteric ACh Binding Sites; 2.2 Accessory Subunits; 2.3 Subunit Stoichiometry; 3 Native Subtypes; 3.1 Techniques for Studying Native nAChRs; 3.2 Autoradiographic Studies; 3.3 Biochemical and Pharmacological Studies of Native Subtypes; 3.3.1 Non alpha Bungarotoxin-Sensitive Receptors; 3.3.2 alpha Bungarotoxin-Sensitive Receptors; 4 Conclusions; Acknowledgments; References; 2 Genetics of Smoking Behaviour; Abstract; 1 Introduction 327 $a2 Genome-Wide Association Studies3 Phenotype Refinement; 3.1 In Vitro Studies and Animal Models; 3.2 Candidate Gene Follow-up Studies; 3.3 Recall-by-Genotype Studies; 4 New and Emerging Technologies; 5 Conclusions and Future Directions; References; 3 Pharmacogenetics of Nicotine and Associated Smoking Behaviors; Abstract; 1 Introduction; 2 Pharmacogenetics of Nicotine Pharmacokinetics; 2.1 Genetic Variation in Nicotine Metabolism; 2.1.1 Cytochrome P450 2A6 (CYP2A6); 2.1.2 3HC/COT as a Biomarker of CYP2A6 Enzymatic Activity; 2.1.3 Effect of CYP2A6 Genetic Variation on Smoking Behaviors 327 $a2.1.4 Acquisition of Smoking Behaviors2.1.5 Cigarette Consumption and Smoking Topography; 2.1.6 Nicotine Dependence; 2.1.7 Cessation and Response to Pharmacotherapies; 2.1.8 Interethnic Variation in CYP2A6 and Smoking Behaviors; 2.1.9 Cytochrome P450 2B6 (CYP2B6); 2.1.10 Effect of CYP2B6 Genetic Variation on Smoking Behaviors; 2.1.11 Cytochrome P450 2A13 (CYP2A13); 2.1.12 Flavin-Containing Monooxygenases (FMOs); 2.1.13 Association of FMO1 and FMO3 Genetic Variation with Nicotine Metabolism and Smoking Behaviors; 2.1.14 UDP-Glucuronyltransferases (UGTs) 327 $a2.1.15 Association of UGT1A and UGT2B Genetic Variation with Nicotine Metabolism and Smoking Behaviors2.2 Genetic Variation in the Renal Elimination of Nicotine; 3 Pharmacogenetics of Nicotine's Central Nervous System Targets; 3.1 Genetic Variation in Nicotinic Acetylcholine Receptors; 3.1.1 Acquisition of Smoking Behaviors; 3.1.2 Cigarette Consumption and Smoking Topography; 3.1.3 Nicotine Dependence; 3.1.4 Cessation and Response to Pharmacotherapies; 3.2 Genetic Variation in the Dopaminergic System; 3.2.1 Dopamine Transporters; 3.2.2 Likelihood of Being a Smoker 327 $a3.2.3 Acquisition of Smoking Behaviors3.2.4 Response to Smoking Cues; 3.2.5 Cessation and Response to Pharmacotherapies; 3.2.6 Dopamine Metabolism; 3.2.7 Likelihood of Being a Smoker; 3.2.8 Cigarette Consumption; 3.2.9 Nicotine Dependence; 3.2.10 Cessation and Response to Pharmacotherapies; 3.2.11 Dopamine Receptors; 3.2.12 Initiation; 3.2.13 Cigarette Consumption; 3.2.14 Nicotine Dependence; 3.2.15 Cessation and Response to Pharmacotherapies; 3.3 Genetic Variation in the Serotonergic System; 3.3.1 Serotonin Synthesis; 3.3.2 Likelihood of Being a Smoker and Initiation 327 $a3.3.3 Serotonin Transporter 330 $aThe primary purpose of this book and its companion volume The Neuropharmacology of Nicotine Dependence is to explore the ways in which recent studies on nicotine and its role in tobacco addiction have opened our eyes to the psychopharmacological properties of this unique and fascinating drug. While the present volume considers the molecular and genetic factors which influence behavioral responses to nicotine and how these may impact on the role of nicotine in tobacco dependence, the book The Neuropharmacology of Nicotine Dependence focuses on the complex neural and psychological mechanisms that mediate nicotine dependence in experimental animal models and their relationship to tobacco addiction in humans.  These volumes will provide readers with a contemporary overview of current research on nicotine psychopharmacology and its role in tobacco dependence from leaders in this field of research and will hopefully prove valuable to those who are developing their own research programmes in this important topic. CTBN Vol 23 The Behavioral Genetics of Nicotine and Tobacco The primary purpose of this book and its companion volume The Neuropharmacology of Nicotine Dependence is to explore the ways in which recent studies on nicotine and its role in tobacco addiction have opened our eyes to the psychopharmacological properties of this unique and fascinating drug. While the present volume considers the molecular and genetic factors which influence behavioral responses to nicotine and how these may impact on the role of nicotine in tobacco dependence, the book The Neuropharmacology of Nicotine Dependence focuses on the complex neural and psychological mechanisms that mediate nicotine dependence in experimental animal models and their relationship to tobacco addiction in humans.  These volumes will provide readers with a contemporary overview of current research on nicotine psychopharmacology and its role in tobacco dependence from leaders in this field of research and will hopefully prove valuable to those who are developing their own research programmes in this important topic. 410 0$aCurrent Topics in Behavioral Neurosciences,$x1866-3370 ;$v23 606 $aHuman genetics 606 $aNeurosciences 606 $aPharmacology 606 $aPsychopharmacology 606 $aBehavioral sciences 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aPsychopharmacology$3https://scigraph.springernature.com/ontologies/product-market-codes/H53010 606 $aBehavioral Sciences$3https://scigraph.springernature.com/ontologies/product-market-codes/L13009 615 0$aHuman genetics. 615 0$aNeurosciences. 615 0$aPharmacology. 615 0$aPsychopharmacology. 615 0$aBehavioral sciences. 615 14$aHuman Genetics. 615 24$aNeurosciences. 615 24$aPharmacology/Toxicology. 615 24$aPsychopharmacology. 615 24$aBehavioral Sciences. 676 $a363.19 702 $aBalfour$b David J.K$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMunafò$b Marcus R$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298277703321 996 $aThe Neurobiology and Genetics of Nicotine and Tobacco$92533176 997 $aUNINA LEADER 05170nam 22005655 450 001 9911047661903321 005 20251119120405.0 010 $a3-031-93275-7 024 7 $a10.1007/978-3-031-93275-5 035 $a(CKB)43368462900041 035 $a(MiAaPQ)EBC32421533 035 $a(Au-PeEL)EBL32421533 035 $a(DE-He213)978-3-031-93275-5 035 $a(EXLCZ)9943368462900041 100 $a20251119d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCultural Heritage-Based Sustainable Tourism Approaches /$fedited by Eliana Martinelli, Eduardo Cândido Cordeiro Gonçalves, Rui Alexandre Marçal Dias Castanho, Tatjana Pivac 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (466 pages) 225 1 $aAdvances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,$x2522-8722 311 08$a3-031-93274-9 327 $aTopic 1 Heritage Preservation and Management -- Chapter 1 Transforming industrial spaces: Exploring the tourism potential of La Neomudéjar (Madrid, Spain) -- Chapter 2 Highlights on the conservation management systems of cultural heritage properties in Southeast Asia developing countries after the closure due to the COVID 19 pandemic -- Chapter 3 Adaptive reuse of Japanese vernacular built heritage as Conservation Strategy and Sustainable Tourism Driver -- Chapter 4 Cultural Tourism and Local Produce: Harissa, Cultural Heritage of Humanity?Souk el Felfel, Nabeul, as a Case Study -- Chapter 5 Costa Rican Indigenous People: Cultural Identity, Language and Protectionism -- Chapter 6 Mitigating Overtourism with New Forms of Cultural Tourism in Adriatic: The Potential Role of Ancient Maritime Wine Routes -- Topic 2 Heritage Awarness and Services Assessment -- Chapter 7 Analysis on the technology and structure of Vernacular Architecture The case of Gjirokastra through site works and BIM -- Chapter 8 Investigation on the Role of Urban Morphology in Improving Outdoor Thermal Comfort in Jaipur Old City -- Chapter 9 Visitors' perceptions of one of Porto's most emblematic tourist attractions the Clérigos Tower -- Chapter 10 Exploring the Representation of Douro's Landscape in Visual Identity -- Chapter 11 The walking trails in the municipality of Valongo (Portugal) -- Chapter 12 Sustainable representations of tourism on digital media: The View of Central Portugal -- Chapter 13 The impact of the mental image on tourism in the digital age: a comparative analysis of "Santorini" and" Sidi Bou Said" -- Chapter 14 Services Assessment by Hotel Managers in the Douro Valley and Hotel Ratings -- Chapter 15 Views of Douro Valley visitors regarding the caliber of services: Learning about the hospitality industry through text -- Topic 3 Sustainable Tourism Practices -- Chapter 16 Projected image of a tourist route: The case of Plitvice Lakes National Park, Croatia -- Chapter 17 Creating Sustainable Experiences in Gastronomy Tourism What did Jesus eat and drink Last Supper? -- Chapter 18 Co creation of Sustainable Experiences at Creative Tourism Events in Georgia -- Chapter 19 Cultural Tourism and Climate Change Challenges and Adaptations in Italian UNESCO Sites -- Chapter 20 Ecotourism and enhancement of cultural ecosystem services in protected areas the case of Maiella National Park -- Chapter 21 Geotourism in the era of digital communication: developing a model for online content analysis based on Portuguese Geoparks. 330 $aThis book leads us into the crossing of cultural heritage, sustainability, and tourism. As global challenges surrounding environmental degradation and cultural decay intensify, this book carries together various perspectives to redefine the role of tourism as a catalyst for favorable change. From innovative strategies for heritage preservation to evaluating sustainable tourism practices, this book offers a refreshed perspective on the travel industry's potential to encourage cultural, environmental, and economic sustainability. With contributions from academics, professionals, and thought leaders, it provides actionable insights for developing tourism models that respect ecological limits while preserving cultural identity. 410 0$aAdvances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,$x2522-8722 606 $aSustainability 606 $aCultural property 606 $aTourism 606 $aSustainability 606 $aCultural Heritage 606 $aTourism Economics 615 0$aSustainability. 615 0$aCultural property. 615 0$aTourism. 615 14$aSustainability. 615 24$aCultural Heritage. 615 24$aTourism Economics. 676 $a304.2 700 $aMartinelli$b Eliana$01212660 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911047661903321 996 $aCultural Heritage-Based Sustainable Tourism Approaches$94476318 997 $aUNINA