LEADER 04464nam 22007095 450 001 9910298277503321 005 20200702164347.0 010 $a94-017-9753-6 024 7 $a10.1007/978-94-017-9753-5 035 $a(CKB)3710000000379462 035 $a(EBL)3109152 035 $a(SSID)ssj0001465040 035 $a(PQKBManifestationID)11755341 035 $a(PQKBTitleCode)TC0001465040 035 $a(PQKBWorkID)11459993 035 $a(PQKB)11397289 035 $a(DE-He213)978-94-017-9753-5 035 $a(MiAaPQ)EBC3109152 035 $a(PPN)184893704 035 $a(EXLCZ)993710000000379462 100 $a20150327d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSingle Cell Sequencing and Systems Immunology /$fedited by Xiangdong Wang 205 $a1st ed. 2015. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2015. 215 $a1 online resource (184 p.) 225 1 $aTranslational Bioinformatics,$x2213-2775 ;$v5 300 $aDescription based upon print version of record. 311 $a94-017-9752-8 320 $aIncludes bibliographical references at the end of each chapters. 327 $aPreface -- Significance of Single Cell Sequencing in Future Medicine -- Uncovering Phenotypes with Supercells: Applications to Single-Cell Sequencing -- Single-Cell Sequencing of Microorganisms -- Application of single-cell sequencing in dynamic transcriptomes -- System Immunology in Metabolic Research of Dendritic Cells -- FOXP3+ Treg Cells and Systems Biology Approaches to Studying Their Function -- ??T Cells and ??T Cells -- Prolymphocyte: Lymphocytes and Bioinformatics -- Lymphocytes in liver cancer -- Early biomarkers of hepatocyte necrosis -- Protocol of Single Cell Isolation by Flow Cytometry -- Single-cell based omics-the new era of human disease and medicine -- Cancer bioinformatics.         . 330 $aThe volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author?s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects.   Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.  . 410 0$aTranslational Bioinformatics,$x2213-2775 ;$v5 606 $aImmunology 606 $aSystems biology 606 $aProteomics 606 $aCell biology 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aSystems Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L15010 606 $aProteomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L1403X 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 615 0$aImmunology. 615 0$aSystems biology. 615 0$aProteomics. 615 0$aCell biology. 615 14$aImmunology. 615 24$aSystems Biology. 615 24$aProteomics. 615 24$aCell Biology. 676 $a616.0790285 702 $aWang$b Xiangdong$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298277503321 996 $aSingle Cell Sequencing and Systems Immunology$92513403 997 $aUNINA