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024 7 $a10.1007/978-94-017-7212-9
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035   $a(DE-He213)978-94-017-7212-9
035   $a(MiAaPQ)EBC2095789
035   $z(PPN)25886575X
035   $a(PPN)186028261
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100   $a20150525d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aDNA Replication - Damage from Environmental Carcinogens /$fby Huidong Zhang
205   $a1st ed. 2015.
210  1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2015.
215   $a1 online resource (51 p.)
225 1 $aSpringerBriefs in Biochemistry and Molecular Biology,$x2211-9353 ;$v17
300   $aDescription based upon print version of record.
311   $a94-017-7211-8 
311   $a94-017-7212-6 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aDNA replication -- Disturbances of the DNA replication system -- Fate of DNA replisome upon encountering DNA damage -- External Causes for DNA Damage -- Effect of environmental carcinogens on cellular physiology -- Protocols for studies of bypass of DNA damage by DNA polymerase.
330   $aThis book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health.
410  0$aSpringerBriefs in Biochemistry and Molecular Biology,$x2211-9353 ;$v17
606   $aNucleic acids
606   $aCell biology
606   $aPharmacology
606   $aNucleic Acid Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14011
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
615  0$aNucleic acids.
615  0$aCell biology.
615  0$aPharmacology.
615 14$aNucleic Acid Chemistry.
615 24$aCell Biology.
615 24$aPharmacology/Toxicology.
676   $a571.87836
700   $aZhang$b Huidong$4aut$4http://id.loc.gov/vocabulary/relators/aut$01064054
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910298276503321
996   $aDNA Replication - Damage from Environmental Carcinogens$92536135
997   $aUNINA