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010   $a3-319-15518-0
024 7 $a10.1007/978-3-319-15518-0
035   $a(CKB)3710000000399926
035   $a(EBL)2095754
035   $a(SSID)ssj0001500692
035   $a(PQKBManifestationID)11834291
035   $a(PQKBTitleCode)TC0001500692
035   $a(PQKBWorkID)11521064
035   $a(PQKB)10991568
035   $a(DE-He213)978-3-319-15518-0
035   $a(MiAaPQ)EBC2095754
035   $a(PPN)18548767X
035   $a(EXLCZ)993710000000399926
100   $a20150414d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aToxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances /$fedited by Jamie C. DeWitt
205   $a1st ed. 2015.
210  1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2015.
215   $a1 online resource (500 p.)
225 1 $aMolecular and Integrative Toxicology,$x2168-4219
300   $aDescription based upon print version of record.
311   $a3-319-15517-2 
327   $aPerfluorinated compounds: An overview -- Analysis of PFASs in biological tissues and fluids -- PFASs in the general population -- PFAS Biomonitoring in Higher Exposed Populations -- Perfluorinated Alkyl Acids in Wildlife -- Metabolism and Pharmacokinetics -- Metabolic EffectsPFAS -- Developmental Toxicity -- Neurotoxicity -- Immunotoxicity of Perfluoroalkylated Compounds -- Effects of PFOA on Endocrine-related Systems -- Carcinogenicity of Perfluoroalkyl Compounds -- Epidemiological Findings -- Dosimetric Anchoring of Toxicological Studies -- Human Health Risk Assessment of Perfluoroalkyl Acids -- Systematic Review, An Illustration of Increased Transparency in a Framework for Evaluating Immunotoxicity Associated with PFOA and PFOS Exposure -- Toxicology data for alternative ?short-chain? fluorinated substances -- Conclusions and recommendations.  .
330   $aThis book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of metabolism and toxicological effects by organ system/developmental stage, and aspects of PFAS toxicity that are driving PFAS research and regulatory oversight. Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances provides critical assessments of the most controversial topics surrounding toxicological evaluation of PFASs to give readers an expert perspective on the issues. Emphasis is placed on the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health. This book will be a useful resource for toxicologists, environmental chemists, risk assessors, and researchers with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances.
410  0$aMolecular and Integrative Toxicology,$x2168-4219
606   $aPharmacology
606   $aEnvironmental health
606   $aEcotoxicology
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aEnvironmental Health$3https://scigraph.springernature.com/ontologies/product-market-codes/U18005
606   $aEcotoxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/U25001
615  0$aPharmacology.
615  0$aEnvironmental health.
615  0$aEcotoxicology.
615 14$aPharmacology/Toxicology.
615 24$aEnvironmental Health.
615 24$aEcotoxicology.
676   $a628.52
702   $aDeWitt$b Jamie C$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298275803321
996   $aToxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances$92513399
997   $aUNINA