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Jahrhunderts$9942043 997 $aUNISA LEADER 04261nam 22006735 450 001 9910298273703321 005 20200706044244.0 010 $a3-319-12730-6 024 7 $a10.1007/978-3-319-12730-9 035 $a(CKB)3710000000315944 035 $a(EBL)1967280 035 $a(SSID)ssj0001407874 035 $a(PQKBManifestationID)11876787 035 $a(PQKBTitleCode)TC0001407874 035 $a(PQKBWorkID)11411052 035 $a(PQKB)11559654 035 $a(DE-He213)978-3-319-12730-9 035 $a(MiAaPQ)EBC1967280 035 $a(PPN)183151178 035 $a(EXLCZ)993710000000315944 100 $a20141211d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aResistance to Photodynamic Therapy in Cancer /$fedited by Valentina Rapozzi, Giulio Jori 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (251 p.) 225 1 $aResistance to Targeted Anti-Cancer Therapeutics,$x2196-5501 ;$v5 300 $aDescription based upon print version of record. 311 $a3-319-12729-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aBasic and Clinical Aspects of photodynamic Therapy -- Mechanisms of Resistance to Photodynamic Therapy -- Tumor Vascular Microenvironment Determines responsiveness to Photodynamic Therapy -- Autophagy Pathways Activated in Response to PDT Contribute to Cell Resistance Against ROS Damage -- Methods to isolate the Resistant Cells to Photodynamic Therapy -- GRP78-Targeting Subtilase Cytotoxin Sensitizes Cancer Cells to Photodynamic Therapy -- Optimization of Photodynamic Therapy Response by Survivin Gene Knockdown in Human Metastatic Breast Cancer -- Cellular Targets and Molecular Responses Associated with Photodynamic Therapy -- The Use of Nanoparticle-Delivered Photosensitizers Can Overcome the Development of Resistance to PDT in Tumors -- Mechanisms of tumor cells resistance to ALA/PDT -- Overcoming the Resistance of Meolanoma to Photodynamic Therapy. 330 $aThis volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. 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