LEADER 05684nam 22006495 450 001 9910298273303321 005 20200702052116.0 010 $a4-431-55200-6 024 7 $a10.1007/978-4-431-55200-0 035 $a(CKB)3710000000311826 035 $a(EBL)1966203 035 $a(SSID)ssj0001407841 035 $a(PQKBManifestationID)11888709 035 $a(PQKBTitleCode)TC0001407841 035 $a(PQKBWorkID)11410058 035 $a(PQKB)11447380 035 $a(DE-He213)978-4-431-55200-0 035 $a(MiAaPQ)EBC1966203 035 $a(PPN)183148428 035 $a(EXLCZ)993710000000311826 100 $a20141205d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAmebiasis $eBiology and Pathogenesis of Entamoeba /$fedited by Tomoyoshi Nozaki, Alok Bhattacharya 205 $a1st ed. 2015. 210 1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2015. 215 $a1 online resource (567 p.) 300 $aDescription based upon print version of record. 311 $a4-431-55199-9 320 $aIncludes bibliographical references. 327 $aPreface -- 1 Introduction -- 2 The continuously expanding universe of Entamoeba -- 3 The genomics of Entamoebae: insights and challenges -- 4 Multilocus sequence typing system (MLST): Genetic diversity and genetic components to virulence -- 5 The tRNA gene-linked STRs and other genetic typing methods -- 6 Genetic manipulation techniques -- 7 Surveying Entamoeba histolytica transcriptome using massively parallel cDNA sequencing -- 8 Ribosomal RNA Genes and their Regulation in Entamoeba histolytica -- 9 Small RNAs and regulation of gene expression in Entamoeba histolytica -- 10 The Biology of Retrotransposition in Entamoeba histolytica -- 11 Entamoeba histolytica: Bridging the gap between environmental stress and epigenetic regulation -- 12 Phagocytosis in Entamoeba histolytica -- 13 Signalling pathways in E. histolytica -- 14 Transmembrane Kinases and their role in E. histolytica pathogenesis -- 15 Cell surface molecules as virulence determinants in Entamoeba histolytica -- 16 Mechanism of cell division in Entamoeba histolytica -- 17 Molecular basis of the trafficking of cysteine proteases and other soluble lysosomal proteins in Entamoeba histolytica -- 18 Mitosomes in Entamoeba histolytica -- 19 Metabolomic analysis of Entamoeba biology -- 20 Glucose metabolism and its controlling mechanisms in Entamoeba histolytica -- 21 Structural Biology of Cysteine Biosynthetic Pathway Enzymes -- 22 Archetypical and specialized DNA replication proteins in Entamoeba histolytica -- 23 Pathology, pathogenesis and experimental amebiasis -- 24 Innate Host Defenses in the Gut -- 25 Cysteine peptidases in pathogenesis -- 26 Host immunity and tissue destruction during liver abscess formation -- 27 The Effect of E. histolytica on Muc2 Mucin and Intestinal Permeability -- 28 Human Genetic Susceptibility to Amebiasis -- 29 Immune Response in Human Amoebiasis: a protective response? -- 30 Metronidazole and the Redox Biochemistry of Entamoeba histolytica -- 31 Thioredoxin Reductase and its Role as a New Drug Target -- 32 Drug development: old drugs and new lead -- 33 HETEROCYCLIC LEAD COMPOUNDS AGAINST AMOEBIASIS. 330 $aThis book documents and presents new developments in the study of amebiasis, one of the neglected tropical diseases. Nearly 50 million people worldwide are infected with the pathogen Entamoeba histolytica, causing large-scale morbidity and mortality particularly in developing countries. This book will help clinicians for better diagnosis and management of the disease, researchers for initiating research projects on some of the poorly understood aspects of the disease and the pathogen, and students for updating their knowledge. The subjects covered range from genomics and molecular and cell biology to drug resistance and new drug development, highlighting major advances in recent years in our understanding due to rapid progress in genomic and other biomedical technologies, such as visualization of molecular processes. Most of the chapters provide recent information based on latest publications. A few chapters describe some of the critical methodological issues that will be helpful for students and researchers interested in getting into the field. The contributing authors include almost all the active researchers and clinicians from around the world. This book will be a useful primary material and a valuable source of information for anyone interested in understanding amebiasis, its diagnosis, and treatment. It will also be useful to those who are interested in learning about the biology of early branching eukaryotes and protist pathogens. 606 $aParasitology 606 $aBacteriology 606 $aPathology 606 $aParasitology$3https://scigraph.springernature.com/ontologies/product-market-codes/B19002 606 $aBacteriology$3https://scigraph.springernature.com/ontologies/product-market-codes/L23012 606 $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X 615 0$aParasitology. 615 0$aBacteriology. 615 0$aPathology. 615 14$aParasitology. 615 24$aBacteriology. 615 24$aPathology. 676 $a579.3 676 $a610 676 $a616.07 676 $a616.96 702 $aNozaki$b Tomoyoshi$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBhattacharya$b Alok$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298273303321 996 $aAmebiasis$9775347 997 $aUNINA