LEADER 06298nam 22007455 450 001 9910298273203321 005 20200630061556.0 010 $a3-319-12253-3 024 7 $a10.1007/978-3-319-12253-3 035 $a(CKB)3710000000343582 035 $a(EBL)1969307 035 $a(SSID)ssj0001424544 035 $a(PQKBManifestationID)11789943 035 $a(PQKBTitleCode)TC0001424544 035 $a(PQKBWorkID)11363961 035 $a(PQKB)10686325 035 $a(DE-He213)978-3-319-12253-3 035 $a(MiAaPQ)EBC1969307 035 $a(PPN)183517261 035 $a(EXLCZ)993710000000343582 100 $a20150129d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMulti-Targeted Approach to Treatment of Cancer$b[electronic resource] /$fedited by Varsha Gandhi, Kapil Mehta, Rajesh Grover, Sen Pathak, Bharat B. Aggarwal 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Adis,$d2015. 215 $a1 online resource (407 p.) 300 $aDescription based upon print version of record. 311 $a3-319-12252-5 320 $aIncludes bibliographical references. 327 $aContents; Contributors; Part I: Genetics/Genome/Microenvironment; Chapter 1: Diversity of Chromosomal Characteristics Among Mammals: With Special Reference to Laboratory Mouse in Cancer Resear...; 1.1 Introduction; 1.2 Do Large Size Mammals Have Longer and High Number of Chromosomes?; 1.3 Do X and Y Chromosomes Exist Intact in All Mammals?; 1.4 Distribution of Constitutive Heterochromatin in Mammalian Species; 1.5 Locations of Ribosomal Cistrons in Mammalian Chromosomes; 1.6 Distribution of Telomeric DNA in Mammalian Species 327 $a1.7 Laboratory Mouse: Is the Animal Model or Muddle in Cancer Research1.8 Human Cloning and Producing Mini-Organs in Culture; References; Chapter 2: Genome-Based Multi-targeting of Cancer: Hype or Hope?; 2.1 Introduction; 2.2 Cancer Is an Age-Old Disease; 2.3 Cancer Is a Disease of Old Age; 2.4 Cancer Is More Common in Western/Developed Countries; 2.5 Cancer Is a Multigenic Disease; 2.6 Target-Specific Anticancer Drugs; 2.7 Anticancer Potential of Targeted Drugs; 2.8 Benefits of Most Targeted Drugs Is Marginal; 2.9 Most Targeted Drugs Are Highly Expensive 327 $a2.10 Adverse Effects Associated with Targeted Therapies2.11 Multi-targeted Drugs Derived from Mother Nature Are Needed; Conclusions; References; Chapter 3: Chronic Lymphocytic Leukemia at the Genomic Level; 3.1 Rai and Binet Staging; 3.2 IgVH Gene Mutation and ZAP-70 Status; 3.2.1 IgVH Mutation Status; 3.2.2 ZAP-70 Status; 3.3 Cytogenetic Abnormalities; 3.3.1 13q14 Deletion; 3.3.2 17p Deletion; 3.3.3 11q Deletion; 3.3.4 Trisomy 12; 3.4 Genomics of CLL; 3.4.1 WGS and WES; 3.4.1.1 NOTCH1; 3.4.1.2 SF3B1; 3.4.1.3 BIRC3; 3.4.1.4 XPO1; 3.4.1.5 MYD88; 3.4.1.6 Clonal Evolution in CLL 327 $a3.5 Transcriptome ProfilingReferences; Chapter 4: Apoptosis Pathways in Chronic Lymphocytic Leukemia: Role of the Microenvironment and Therapeutic Strategies; 4.1 Introduction; 4.2 Intrinsic and Extrinsic Factors Contribute to Biology of CLL Cells; 4.2.1 Intrinsic Factors: Genetic Aberrations in CLL; 4.2.2 Intrinsic Factors: Apoptotic Imbalance in CLL Cells; 4.2.3 Extrinsic Factors: Contribution of the Microenvironment to CLL Cell Survival; 4.3 Role of Apoptosis Pathway Members in CLL Pathophysiology; 4.3.1 B-cell Receptor, TNF Receptor Super Family, DED, and CARD Family 327 $a4.3.2 NF-kappaB, Caspase, and IAP Families4.3.3 Bcl-2 Family Antiapoptotic and Proapoptotic Proteins; 4.4 Microenvironment-Dependent Regulation of Apoptotic Pathway Proteins; 4.5 Therapeutic Strategies to Counter Survival Signals in CLL; 4.5.1 CLL Therapy: Standard of Care; 4.5.2 CLL Therapy: Targeting BCR Pathway; 4.5.3 CLL Therapy: Targeting Bcl-2 and IAPs; Conclusions; References; Chapter 5: Tumor-Associated Macrophages in Tumor Progression: From Bench to Bedside; 5.1 Introduction; 5.2 TAM Origin and Accumulation 327 $a5.3 Polarized Activation of Macrophages and Cancer-Related Functional Aspects 330 $aIn this book, clinicians and basic scientists from USA, India, and other countries discuss the rationales and clinical experiences with targeted approaches to treat, prevent, or manage cancer. Cancer is a hyperproliferative disorder that is regulated by multiple genes and multiple cell signaling pathways. Genomics, proteomics, and metabolomics have revealed that dysregulation of dozens of genes and their products occur in any given cell type that ultimately leads to cancer. These discoveries are providing unprecedented opportunities to tackle cancer by multi-faceted approaches that target these underpinnings. This book emphasizes a multi-targeted approach to treating cancer, the focus of the 5th International Conference on Translational Cancer Research that was held in Vigyan Bhawan, Delhi (India) from Feb 6-9, 2014. 606 $aCancer research 606 $aPharmaceutical technology 606 $aOncology   606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 615 0$aCancer research. 615 0$aPharmaceutical technology. 615 0$aOncology  . 615 14$aCancer Research. 615 24$aPharmaceutical Sciences/Technology. 615 24$aOncology. 676 $a610 676 $a614.5999 676 $a615.19 676 $a616994 702 $aGandhi$b Varsha$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMehta$b Kapil$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGrover$b Rajesh$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aPathak$b Sen$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aAggarwal$b Bharat B$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298273203321 996 $aMulti-Targeted Approach to Treatment of Cancer$92502113 997 $aUNINA