LEADER 06049nam 22007815 450 001 9910298273003321 005 20200705010904.0 010 $a3-642-31974-2 024 7 $a10.1007/978-3-642-31974-7 035 $a(CKB)3710000000315935 035 $a(EBL)1968261 035 $a(SSID)ssj0001407849 035 $a(PQKBManifestationID)11807638 035 $a(PQKBTitleCode)TC0001407849 035 $a(PQKBWorkID)11412293 035 $a(PQKB)11119112 035 $a(DE-He213)978-3-642-31974-7 035 $a(MiAaPQ)EBC1968261 035 $a(PPN)18315021X 035 $a(EXLCZ)993710000000315935 100 $a20141211d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aEpigenetic Mechanisms in Cellular Reprogramming$b[electronic resource] /$fedited by Alexander Meissner, Jörn Walter 205 $a1st ed. 2015. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2015. 215 $a1 online resource (244 p.) 225 1 $aEpigenetics and Human Health,$x2191-2262 300 $aDescription based upon print version of record. 311 $a3-642-31973-4 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPreface; Glossary; Contents; The Oocyte Determinants of Early Reprogramming; 1 Controversies Surrounding Oocyte Reprogramming; 2 A Brief History of SCNT; 3 The Uniqueness of the Oocyte: More than Totipotency; 4 Qualitative Aspects of Oocyte-Mediated Nuclear Reprogramming; 4.1 Characteristic Traits of the Oocyte Are Species Specific; 4.2 Transcriptional Activity in Germinal Vesicle-Stage Oocytes; 4.3 Different Maturation States and Accompanying Chromatin Configuration of Recipient Oocytes for SCNT; 5 Quantitative Aspects of Oocyte-Mediated Nuclear Reprogramming 327 $a5.1 Amount of Reprogramming Factors5.2 Kinetics of Reprogramming; 6 Gene Expression in Oocytes; 7 The Elusive Reprogramming Factors; 8 Using Transcriptomics and Proteomics to Search for the Molecular Fingerprint Indicative of an Oocyte´s Reprogramming Potenti...; 8.1 Candidate Gene Approach; 8.2 Transcriptome Analysis; 8.3 Proteome Analysis; Conclusion; References; Stella and Zygotic Reprogramming; 1 Stella; 1.1 Identification of Stella; 1.2 Expression Pattern of Stella; 1.3 Gene Disruption Analysis of Stella; 2 Epigenetic Reprogramming in Zygotes 327 $a2.1 Active Loss of 5mC in Zygotic Paternal Genome2.2 Protection of Imprinted Genes and Repetitive Sequences in Zygotes; 2.3 Involvement of 5hmC and Tet Proteins in Active Loss of 5mC; 2.4 Histone Modification in Zygotes; 3 Mechanism of Stella-Mediated Protection of 5mC in Zygotes; 3.1 Stella Protects Active Loss of 5mC in Zygotes; 3.2 Stella Protects Imprinted Genes and Repetitive Sequences; 3.3 Protective Function of Stella Depends on H3K9me2; 3.4 Mechanism of Stella-Mediated Protection of 5mC in Zygotes; 4 Perspectives; References; Histone Variants and Reprogramming in Early Development 327 $a1 Mammalian Development: Context and Early Epigenetic Reprogramming2 Mechanisms of Epigenetic Reprogramming and Chromatin Remodelling in the Early Embryo; 3 The Components of the Chromatin Change as Development Proceeds; 4 Histone Variants as Regulators of Epigenetic Information During Reprogramming; 5 H3.3 and De Novo Establishment of Heterochromatin; 6 H3 Variants: A Conserved Function in the Germline; 7 Variants of H2A: The Case of MacroH2A; 8 H2A.Z Shows a Dynamic Localisation During Early Reprogramming in Embryos 327 $a9 High Endogenous Levels of Phosphorylated H2A.X Are Characteristic of Early Embryos10 Barr Body-Deficient H2A: H2A.B; References; DNA Methylation Reprogramming in Preimplantation Development; 1 Epigenetic Profiles in Mature Gametes; 2 DNA Methylation Reprogramming in the Zygote; 3 The Mechanisms of DNA Demethylation; 4 DNA Methylation Reprogramming in Further Preimplantation Development; 5 Roles of Dnmts in Regulating DNA Methylation in Early Embryos; 5.1 Dnmt1; 5.2 Dnmt3a, Dnmt3L and Dnmt3b; 6 DNA Methylation Reprogramming in SCNT-Derived Embryos 327 $a7 Histone Modifications and DNA Methylation Crosstalk 330 $aThe ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human health and disease. This book presents the basic biology involved, including key mechanistic insights into this rapidly growing field. 410 0$aEpigenetics and Human Health,$x2191-2262 606 $aHuman genetics 606 $aCell biology 606 $aSystems biology 606 $aNucleic acids 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aSystems Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L15010 606 $aNucleic Acid Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14011 615 0$aHuman genetics. 615 0$aCell biology. 615 0$aSystems biology. 615 0$aNucleic acids. 615 14$aHuman Genetics. 615 24$aCell Biology. 615 24$aSystems Biology. 615 24$aNucleic Acid Chemistry. 676 $a616.0277 702 $aMeissner$b Alexander$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWalter$b Jörn$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298273003321 996 $aEpigenetic Mechanisms in Cellular Reprogramming$92541194 997 $aUNINA